Vaxphoid Injection 25 mcg/0.5 ml is a typhoid polysaccharide vaccine designed to provide active immunization against typhoid fever, a potentially serious systemic infection caused by Salmonella Typhi. The vaccine works by stimulating the body’s immune system to produce protective antibodies against the bacteria, thereby reducing the risk of infection and severe illness.

Typhoid fever is prevalent in areas with poor sanitation and contaminated food or water. Vaccination with Vaxphoid is an effective preventive measure for travelers to endemic regions, as well as for residents in high-risk areas.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Therapeutic Class

• Vaccines & Toxoids

• Active Immunizing Agent

Pharmacology

Vaxphoid contains purified Vi capsular polysaccharide antigen of Salmonella Typhi, which is adsorbed onto a carrier to enhance immunogenicity. Upon intramuscular administration, the antigen triggers the immune system to produce specific antibodies that target the S. Typhi bacteria. These antibodies help neutralize the pathogen and prevent its replication in the bloodstream, thereby protecting against typhoid fever.

The vaccine does not contain live bacteria and cannot cause typhoid infection. Protective antibody levels typically develop within 2–3 weeks after vaccination and last for approximately 2–3 years, after which a booster may be required.

Indications

Vaxphoid Injection is indicated for:

• Active immunization against typhoid fever in individuals aged 2 years and above

• Travelers to regions where typhoid fever is endemic

• Residents in areas with high incidence of typhoid

• Individuals in close contact with typhoid carriers or in environments with poor sanitation

Dosage and Administration

• Adults and children over 2 years: 0.5 ml intramuscularly, usually into the deltoid muscle

• A single dose is generally sufficient for initial protection

• A booster dose may be administered every 2–3 years depending on continued risk of exposure

• The vaccine should not be administered intravenously or intradermally

• Post-vaccination, individuals should be monitored for any immediate adverse reactions

Storage Conditions

• Store at 2°C to 8°C

• Protect from light

• Do not freeze

• Keep out of reach of children

Contraindications

• Known hypersensitivity to any component of the vaccine

• Acute severe febrile illness (vaccination should be deferred until recovery)

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Precautions and Warnings

• Administer with caution to individuals with a history of severe allergic reactions

• Inform the healthcare provider about any chronic illnesses or immune system disorders

• Vaccination does not replace good hygiene practices and safe food and water consumption

Side Effects

Vaxphoid Injection is generally well tolerated. Common side effects include:

• Mild pain, redness, or swelling at the injection site

• Low-grade fever

• Headache or malaise

• Rarely, mild gastrointestinal symptoms such as nausea

Severe allergic reactions are extremely rare but require immediate medical attention.

Pregnancy and Lactation

• Can be administered during pregnancy if clearly indicated

• Safe for use during breastfeeding

Mechanism of Action

Vaxphoid Injection induces active immunity by stimulating the production of anti-Vi antibodies against Salmonella Typhi. These antibodies prevent bacterial colonization and systemic spread, thereby protecting against typhoid fever.