Posac Injection 18 mg/ml contains Posaconazole, a potent broad-spectrum antifungal agent used for the prevention and treatment of serious fungal infections. This intravenous formulation is ideal for patients who cannot take oral antifungals or require rapid systemic therapy. Posac Injection is commonly used in immunocompromised patients, including those undergoing chemotherapy, hematopoietic stem cell transplantation, or suffering from prolonged neutropenia, to prevent invasive fungal infections and manage systemic mycoses.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

Each milliliter of solution contains:

• Posaconazole 18 mg

Mechanism of Action

Posaconazole inhibits the fungal enzyme lanosterol 14α-demethylase, essential for ergosterol synthesis:

• Prevents formation of ergosterol, a critical component of the fungal cell membrane
• Disrupts cell membrane integrity, causing fungal cell death
• Provides broad-spectrum activity against Candida, Aspergillus, and other pathogenic fungi
• Ensures rapid therapeutic levels in systemic circulation via intravenous administration

Indications

Posac Injection is indicated for:

• Prevention of invasive fungal infections in immunocompromised patients
• Treatment of oropharyngeal and systemic candidiasis
• Management of invasive aspergillosis
• Patients at high risk of fungal infections due to chemotherapy, stem cell transplantation, or prolonged neutropenia
• Cases where oral administration is not feasible or absorption is compromised

Dosage and Administration

• Administer intravenously under the supervision of a healthcare professional.
• Dosage and duration depend on patient condition, type, and severity of infection.
• Infuse slowly according to recommended guidelines to avoid infusion-related reactions.
• Monitor liver function and electrolytes during prolonged therapy.

Benefits

• Broad-spectrum antifungal coverage for systemic and invasive infections
• Rapid achievement of therapeutic blood levels through IV administration
• Effective in patients unable to take oral antifungals
• Supports immunocompromised patients in preventing life-threatening infections
• Convenient and reliable hospital-based treatment option

Side Effects

Common side effects may include:

• Nausea and vomiting
• Diarrhea
• Headache
• Fever or infusion-related reactions

Serious side effects, although rare, may include:

• Liver enzyme elevation or hepatotoxicity
• QT interval prolongation
• Severe allergic reactions

Immediate medical attention is required if serious adverse effects occur.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Precautions

• Use with caution in patients with liver impairment or cardiac disease.
• Monitor for drug interactions, especially with medications metabolized by CYP3A4.
• Avoid use in patients with known hypersensitivity to azole antifungals.
• Regular blood tests may be necessary for liver function and therapeutic monitoring.
• Administer in a controlled healthcare setting to manage potential infusion reactions.

Storage

• Store at 2–8°C in a refrigerator
• Protect from light and do not freeze
• Keep vials tightly closed and out of reach of children.