Disartan Tablet 5 mg+40 mg is a dual-action antihypertensive medication containing Amlodipine Besilate 5 mg and Olmesartan Medoxomil 40 mg, formulated for patients with hypertension who require enhanced blood pressure control. This combination therapy leverages the complementary mechanisms of two potent agents to provide effective and sustained reduction of blood pressure, improving cardiovascular outcomes and reducing the risk of hypertension-related complications.

Amlodipine Besilate, a calcium channel blocker, relaxes smooth muscles in the arterial walls, decreasing peripheral vascular resistance and enhancing blood flow. This action reduces blood pressure and helps alleviate angina by improving oxygen delivery to the heart muscle.

Olmesartan Medoxomil, an angiotensin II receptor blocker (ARB), inhibits the vasoconstrictive effects of angiotensin II, promoting vasodilation and lowering blood pressure. It also reduces strain on the heart and protects kidney function, particularly in patients with diabetes or chronic kidney disease.

The combination of these two agents ensures synergistic antihypertensive effects, allowing better blood pressure control than either drug alone, while minimizing the likelihood of adverse effects that might occur with higher doses of single agents.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Indications

Disartan Tablet 5 mg+40 mg is indicated for:

• Treatment of hypertension in adults who require dual therapy for adequate blood pressure control

• Reduction of cardiovascular risk in hypertensive patients with additional risk factors such as diabetes, kidney disease, or heart disease

• Management of patients inadequately controlled on monotherapy with either a calcium channel blocker or an ARB

This formulation is particularly beneficial for patients who need intensive blood pressure management and improved cardiovascular protection.

Dosage and Administration

• Adults: Typically, one tablet orally once daily, with or without food, at the same time each day for consistent blood pressure control.

• The dose may be adjusted by a physician depending on blood pressure response, comorbid conditions, and tolerance.

• Administration tips: Swallow the tablet whole with a glass of water. Avoid splitting, crushing, or chewing to ensure proper absorption and therapeutic effect.

Patients are advised to maintain lifestyle measures including a balanced diet, reduced salt intake, regular exercise, and avoidance of excessive alcohol to optimize treatment outcomes.

Precautions

• Contraindicated in patients with hypersensitivity to Amlodipine, Olmesartan, or any component of the tablet.

• Use cautiously in patients with severe liver or kidney impairment, heart failure, or low blood pressure.

• May cause dizziness or hypotension, particularly after the first dose; avoid driving or operating machinery until the effect on individual tolerance is known.

• Pregnant or breastfeeding women should only use under strict medical supervision; Olmesartan may harm the fetus.

• Regular monitoring of blood pressure, renal function, and serum electrolytes is recommended during treatment.

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Possible Side Effects

Disartan Tablet 5 mg+40 mg is generally well tolerated. Possible side effects include:

• Dizziness, headache, or fatigue

• Peripheral edema (swelling of ankles or feet)

• Flushing or mild gastrointestinal discomfort such as nausea

• Rarely, hypotension, palpitations, or allergic reactions

Severe adverse reactions are uncommon but may include significant hypotension, kidney dysfunction, or elevated potassium levels. Patients should report unusual symptoms promptly.

Storage

Store below 30°C in a cool, dry place, protected from light and moisture. Keep out of reach of children.

Disartan Tablet 5 mg+40 mg provides effective dual antihypertensive therapy, combining calcium channel blockade and angiotensin II receptor antagonism for sustained blood pressure reduction, improved cardiovascular protection, and overall hypertension management under professional supervision.