Losardil 50/12.5 Tablet is a combination antihypertensive medication containing Losartan Potassium 50 mg and Hydrochlorothiazide 12.5 mg. This formulation is designed for adults with hypertension who need more effective blood pressure control than monotherapy with either agent alone. The combination of an angiotensin II receptor blocker (ARB) and a thiazide diuretic provides a synergistic effect, improving blood pressure management and reducing cardiovascular risk.

Losartan works by blocking the action of angiotensin II, a hormone responsible for vasoconstriction, while Hydrochlorothiazide reduces fluid retention by promoting sodium and water excretion through the kidneys. This dual mechanism helps achieve sustained blood pressure reduction, protects the kidneys, and lowers the risk of stroke, heart attack, and heart failure.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Mechanism of Action

The combined action of Losartan and Hydrochlorothiazide in Losardil 50/12.5 Tablet includes:

• Losartan (50 mg):

  • Selectively blocks angiotensin II at AT1 receptors, preventing vasoconstriction.

  • Promotes vasodilation, reducing systemic vascular resistance and lowering blood pressure.

  • Provides renal protection by reducing intraglomerular pressure, especially in diabetic patients with proteinuria.

• Hydrochlorothiazide (12.5 mg):

  • Increases excretion of sodium and water, decreasing blood volume.

  • Reduces peripheral resistance, contributing to long-term blood pressure control.

  • Helps prevent complications from fluid retention associated with hypertension.

The combination ensures enhanced and more consistent antihypertensive efficacy, particularly beneficial for patients whose blood pressure is not adequately controlled with lower doses or monotherapy.

Indications

Losardil 50/12.5 Tablet is indicated for:

• Essential hypertension: Adults requiring moderate blood pressure control.

• Combination therapy: Patients not adequately controlled on a single antihypertensive agent.

• Cardiovascular risk reduction: Lowers the risk of stroke, myocardial infarction, and heart failure.

• Renal protection in diabetes: Reduces proteinuria and slows the progression of kidney disease in type 2 diabetes patients.

It is not suitable for patients who are pregnant, breastfeeding, or have severe kidney or liver disease, or those with hypersensitivity to Losartan or Hydrochlorothiazide.

Dosage and Administration

• The recommended dose is 1 tablet once daily, taken orally with or without food.

• Swallow the tablet whole with water; do not crush or chew.

• Monitor blood pressure, kidney function, and electrolytes regularly to assess treatment response.

• Dose adjustments may be necessary for patients with renal or hepatic impairment.

• Continue dietary modifications, exercise, and salt restriction for optimal blood pressure control.

Precautions

• Avoid during pregnancy, as ARBs can harm the fetus.

• Use caution in patients with low blood pressure, dehydration, or electrolyte imbalances.

• Inform your doctor of all medications being taken, including potassium supplements, other diuretics, or NSAIDs.

• Elderly patients may require closer monitoring due to increased sensitivity to antihypertensive therapy.

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Possible Side Effects

Common side effects may include:

• Dizziness or lightheadedness

• Fatigue or headache

• Mild gastrointestinal disturbances such as nausea or abdominal discomfort

• Increased urination due to the diuretic effect

Rare but serious side effects include:

• Hyperkalemia (high potassium levels)

• Hypotension (excessive reduction in blood pressure)

• Impaired kidney function

• Severe allergic reactions: rash, swelling, or difficulty breathing

Seek immediate medical attention if severe symptoms occur.

Storage

Store below 30°C in a dry place, away from sunlight and moisture. Keep out of reach of children.

Losardil 50/12.5 Tablet provides potent and balanced blood pressure control, combining Losartan and Hydrochlorothiazide for cardiovascular protection, kidney support, and reduced risk of hypertension-related complications.