Ximeprox Pediatric Drop 20 mg/ml is a third-generation oral cephalosporin antibiotic used for the treatment of a wide range of bacterial infections caused by susceptible microorganisms. It contains Cefpodoxime proxetil, a prodrug that is converted in the body to its active form, cefpodoxime. Due to its stability against beta-lactamase enzymes, it is effective against both Gram-positive and Gram-negative bacteria.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Therapeutic Class

Third Generation Cephalosporins

Indications

Ximeprox Pediatric Drop 20 mg/ml is indicated for the treatment of the following infections caused by susceptible organisms:

• Ear, Nose & Throat Infections

  • Acute otitis media caused by Streptococcus pneumoniae, Streptococcus pyogenes, Haemophilus influenzae, and Moraxella catarrhalis (including beta-lactamase–producing strains)

  • Pharyngitis and tonsillitis caused by Streptococcus pyogenes

  • Acute maxillary sinusitis caused by H. influenzae, S. pneumoniae, and M. catarrhalis

• Respiratory Tract Infections

  • Community-acquired pneumonia caused by Streptococcus pneumoniae or Haemophilus influenzae

  • Acute bacterial exacerbation of chronic bronchitis caused by S. pneumoniae, H. influenzae (non–beta-lactamase producing strains), or M. catarrhalis

• Skin and Soft Tissue Infections

  • Infections caused by Staphylococcus aureus and Streptococcus pyogenes

• Urinary Tract Infections

  • Uncomplicated UTIs caused by E. coli, Klebsiella pneumoniae, Proteus mirabilis, or Staphylococcus saprophyticus

• Sexually Transmitted Infections

  • Uncomplicated gonorrhea and rectal gonococcal infections in women caused by Neisseria gonorrhoeae (including penicillinase-producing strains)

Pharmacology

Ximeprox Pediatric Drop 20 mg/ml is an oral third-generation cephalosporin with broad-spectrum antibacterial activity. Cefpodoxime proxetil is rapidly hydrolyzed after absorption to its active metabolite, cefpodoxime. It exhibits high resistance to beta-lactamases and interferes with bacterial cell wall synthesis, resulting in bacterial cell death. Approximately 29–33% of cefpodoxime is excreted unchanged in the urine within 12 hours.

Dosage and Administration

Adults and Adolescents (13 years and older):

• Pharyngitis/Tonsillitis: 100 mg every 12 hours for 5–10 days

• Acute Maxillary Sinusitis: 200 mg every 12 hours for 10 days

• Community-Acquired Pneumonia: 200 mg every 12 hours for 14 days

• Acute Exacerbation of Chronic Bronchitis: 200 mg every 12 hours for 10 days

• Skin and Skin Structure Infections: 400 mg every 12 hours for 7–14 days

• Uncomplicated UTI: 100 mg every 12 hours for 7 days

• Uncomplicated Gonorrhea: Single dose of 200 mg

• Rectal Gonococcal Infection (Women): Single dose of 200 mg

Infants and Pediatric Patients (2 months to 12 years):

• Acute Otitis Media: 5 mg/kg every 12 hours for 5 days

• Pharyngitis/Tonsillitis: 5 mg/kg every 12 hours for 5–10 days

• Acute Maxillary Sinusitis: 5 mg/kg every 12 hours for 10 days

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Drug Interactions

• High doses of antacids (sodium bicarbonate, aluminum hydroxide) and H2-receptor blockers may reduce absorption and peak plasma concentration

• Probenecid inhibits renal excretion of cefpodoxime, increasing plasma levels

Contraindications

Ximeprox Pediatric Drop 20 mg/ml is contraindicated in patients with known hypersensitivity to cephalosporins.

Side Effects

Generally well tolerated. Possible side effects include:

• Diarrhea

• Nausea and vomiting

• Abdominal pain

• Skin rash, urticaria, or itching

Pregnancy and Lactation

Cefpodoxime is classified as US FDA Pregnancy Category B. It should be used during pregnancy only if clearly needed. Cefpodoxime is excreted in human breast milk; caution is advised when administered to nursing mothers.

Precautions and Warnings

• Dose adjustment is required in patients with renal impairment

• Prolonged use may lead to overgrowth of non-susceptible organisms

• Use with caution in patients receiving potent diuretics

Use in Special Populations

• Renal impairment: For creatinine clearance below 30 ml/min, dosing interval should be increased to once daily

• Hepatic impairment: No dosage adjustment required

Reconstitution Instructions

1. Shake the bottle well to loosen the powder

2. Add boiled and cooled water up to the marked level

3. Shake thoroughly until the suspension is uniformly mixed

Storage Conditions

Store in a dry place away from light and heat. Keep out of reach of children.