A-Fenac Gel 1% w/w contains Diclofenac Sodium, a widely used nonsteroidal anti-inflammatory drug (NSAID) formulated for topical application. It is designed to provide targeted relief from pain, inflammation, and swelling associated with musculoskeletal and joint disorders. By delivering diclofenac directly to the affected area, A-Fenac Gel offers effective local action with minimal systemic absorption, thereby reducing the risk of systemic side effects commonly associated with oral NSAIDs.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Indications

A-Fenac Gel 1% w/w is indicated for the relief of pain and inflammation in a variety of conditions, including:

• Muscle pain and stiffness

• Sprains, strains, and sports injuries

• Tendinitis and bursitis

• Backache and neck pain

• Osteoarthritis and other degenerative joint diseases

• Soft tissue rheumatism

• Localized inflammatory conditions following trauma

It is suitable for adults and elderly patients and may be used as an adjunct to other therapies as advised by a healthcare professional.

Therapeutic Class

Topical Nonsteroidal Anti-inflammatory Drugs (NSAIDs)

Pharmacology

Diclofenac Sodium acts by inhibiting cyclooxygenase (COX-1 and COX-2) enzymes, which play a crucial role in the synthesis of prostaglandins. Prostaglandins are mediators responsible for pain, inflammation, and swelling at the site of injury. When applied topically, diclofenac penetrates the skin and accumulates in underlying tissues such as muscles and joints, where it exerts its anti-inflammatory and analgesic effects.

Systemic absorption from topical application is significantly lower compared to oral administration, which helps minimize gastrointestinal, renal, and cardiovascular adverse effects while maintaining effective local symptom control.

Mechanism of Action

A-Fenac Gel 1% w/w reduces pain and inflammation by blocking prostaglandin synthesis at the site of application. This leads to decreased swelling, improved mobility, and relief from discomfort, allowing patients to resume daily activities more comfortably.

Dosage and Administration

• Apply a thin layer of A-Fenac Gel to the affected area 2 to 3 times daily or as directed by a physician

• Gently massage the gel into the skin until fully absorbed

• Wash hands after application unless the hands are the area being treated

The gel should be applied only to intact, healthy skin. Avoid contact with eyes, mouth, mucous membranes, and open wounds. Treatment duration should be limited to the shortest period necessary to achieve symptom relief.

Drug Interactions

Since systemic absorption is low, drug interactions are unlikely. However, caution is advised when used concurrently with other diclofenac-containing products or NSAIDs to avoid cumulative exposure.

Contraindications

A-Fenac Gel 1% w/w is contraindicated in patients with:

• Known hypersensitivity to diclofenac or any component of the formulation

• History of allergic reactions to other NSAIDs

• Damaged, infected, or inflamed skin at the application site

Side Effects

A-Fenac Gel is generally well tolerated. Possible side effects include:

• Local skin irritation, redness, or itching

• Rash or burning sensation at the application site

Systemic side effects are rare due to minimal absorption.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Use in Pregnancy and Lactation

Use during pregnancy, especially in the third trimester, is not recommended unless clearly necessary. The gel should be used with caution during breastfeeding and only under medical supervision.

Storage Conditions

Store below 30°C in a cool, dry place. Keep the tube tightly closed and protected from excessive heat and light. Keep out of reach of children.