Diasulin N Injection 40 IU/ml contains Insulin Human (rDNA, NPH), an intermediate-acting insulin designed for the management of type 1 and type 2 diabetes mellitus. Produced using recombinant DNA technology, this insulin provides reliable basal glycemic control, helping to maintain fasting blood glucose levels and prevent complications associated with long-term hyperglycemia. The 40 IU/ml concentration is suitable for patients requiring smaller or more precise insulin doses.

Composition

• Active Ingredient: Insulin Human (rDNA, NPH)
• Strength: 40 IU/ml

Indications

Diasulin N Injection is indicated for:

• Type 1 diabetes mellitus requiring basal insulin therapy
• Type 2 diabetes mellitus when oral antidiabetic medications are insufficient
• Control of fasting hyperglycemia
• Use as part of a basal-bolus insulin regimen

Mechanism of Action

NPH insulin provides intermediate-acting glucose control by slowly releasing insulin over 12–16 hours after subcutaneous injection. It lowers blood glucose by:

• Promoting cellular uptake of glucose in muscle and fat tissues
• Inhibiting hepatic glucose production
• Supporting protein and lipid metabolism

This results in stable fasting and basal blood glucose levels throughout the day.

Dosage and Administration

• Administer subcutaneously as prescribed by a healthcare professional
• Typically injected once or twice daily depending on individual glucose control needs
• Rotate injection sites to prevent lipodystrophy
• Do not mix with other insulins unless recommended by a physician
• Regular blood glucose monitoring is essential to adjust dosage

Benefits

• Provides predictable intermediate-acting basal insulin coverage
• Supports stable fasting blood glucose control
• Can be used alone or in combination with rapid-acting insulin for basal-bolus therapy
• Recombinant DNA production ensures high purity and low risk of allergic reactions
• Suitable for patients requiring smaller, precise doses

Side Effects

Common side effects may include:

• Hypoglycemia (low blood sugar)
• Injection site reactions such as redness, swelling, or itching
• Mild weight gain

Rare side effects:

• Severe allergic reactions
• Lipodystrophy at repeated injection sites

Seek immediate medical attention if severe hypoglycemia or allergic reactions occur.

Precautions

• Monitor blood glucose regularly
• Adjust dose during illness, stress, or changes in diet or activity
• Use cautiously in patients with kidney, liver, or cardiovascular disease
• Keep a source of fast-acting sugar to manage hypoglycemia

Contraindications

• Hypersensitivity to Insulin Human or any component of the formulation
• Severe hypoglycemia

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Drug Interactions

• May interact with oral antidiabetic drugs, corticosteroids, beta-blockers, diuretics, and other medications affecting blood glucose
• Inform your healthcare provider about all medications currently being taken

Storage

• Store refrigerated at 2–8°C; do not freeze
• Protect from heat and light
• Once opened, in-use vials can be stored at room temperature (below 30°C) for up to 28 days
• Keep out of reach of children.