Tetracef Injection 1 gm/vial is a bactericidal beta-lactam antibiotic. It acts by inhibiting bacterial cell wall synthesis through binding to penicillin-binding proteins (PBPs). This disrupts the final transpeptidation step in peptidoglycan formation, an essential component of the bacterial cell wall. The resulting weakened cell wall leads to osmotic instability and bacterial cell death.
Cefepime demonstrates broad-spectrum activity against Gram-negative organisms while maintaining good efficacy against Gram-positive bacteria. Its resistance to hydrolysis by many beta-lactamases makes it effective against organisms resistant to earlier-generation cephalosporins.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Indications

Tetracef Injection 1 gm is indicated for the treatment of the following infections caused by susceptible microorganisms:

• Moderate to severe pneumonia, including cases associated with bacteremia, caused by Streptococcus pneumoniae, Pseudomonas aeruginosa, Klebsiella pneumoniae, and Enterobacter species

• Febrile neutropenia, for empiric monotherapy in selected patients

• Uncomplicated and complicated urinary tract infections, including pyelonephritis

• Uncomplicated skin and skin structure infections caused by methicillin-susceptible Staphylococcus aureus and Streptococcus pyogenes

• Complicated intra-abdominal infections, when used in combination with metronidazole

Dosage and Administration

Tetracef Injection 1 gm/vial should be administered intravenously over approximately 30 minutes or by deep intramuscular injection when appropriate.

Typical adult dosage includes:

• Pneumonia: 1–2 gm IV every 12 hours

• Febrile neutropenia: 2 gm IV every 8 hours

• Urinary tract infections: 0.5–2 gm IV/IM every 12 hours

• Skin and soft tissue infections: 2 gm IV every 12 hours

• Intra-abdominal infections: 2 gm IV every 12 hours (with metronidazole)

Dosage adjustment is necessary in patients with renal impairment.

Contraindications

• Known hypersensitivity to cefepime, cephalosporins, penicillins, or other beta-lactam antibiotics

Side Effects

Common adverse effects may include:

• Gastrointestinal disturbances such as diarrhea or nausea

• Injection site reactions

• Skin rash or hypersensitivity

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Serious neurological reactions such as encephalopathy, seizures, and myoclonus may occur, particularly in elderly patients or those with renal dysfunction receiving unadjusted doses.

Pregnancy and Lactation

• Pregnancy Category B: Use during pregnancy only if clearly needed

• Cefepime is excreted into breast milk in very low concentrations; caution is advised during breastfeeding

Precautions and Warnings

• Dose adjustment and close monitoring are required in patients with renal impairment

• Prolonged use may result in overgrowth of non-susceptible organisms

• Prescribing without confirmed or strongly suspected bacterial infection increases the risk of antimicrobial resistance

• Caution is advised in patients with a history of gastrointestinal disease, particularly colitis

Storage Conditions

• Store below recommended temperature and protect from light

• Do not use after the expiry date

• Keep out of reach of children

• Prescription-only medicine.