Litizem Tablet 60 mg is a prescription medication containing Diltiazem Hydrochloride, a calcium channel blocker used primarily to treat hypertension, angina pectoris, and certain cardiac arrhythmias. Diltiazem works by relaxing the smooth muscles of the blood vessels and reducing the workload of the heart, thereby improving blood flow and controlling high blood pressure.

This 60 mg formulation is commonly prescribed for adults requiring moderate blood pressure control or management of chronic stable angina. Litizem helps prevent anginal attacks, reduces chest pain frequency, and enhances overall cardiac performance.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Therapeutic Class

• Calcium channel blockers

• Anti-hypertensive and anti-anginal agents

Pharmacology

Diltiazem is a benzothiazepine calcium channel blocker that inhibits the influx of calcium ions through L-type calcium channels in cardiac and vascular smooth muscle. By reducing intracellular calcium levels, Diltiazem produces:

• Vasodilation: Relaxes coronary and peripheral arteries, lowering systemic vascular resistance

• Negative chronotropic effect: Slows heart rate by acting on the sinoatrial (SA) node

• Negative inotropic effect: Reduces myocardial contractility, lowering oxygen demand

Diltiazem is well-absorbed orally, with peak plasma concentrations reached within 1–2 hours. It undergoes extensive hepatic metabolism and has a half-life of approximately 3–4.5 hours, making twice-daily dosing suitable in most cases.

Indications

Litizem Tablet 60 mg is indicated for:

• Hypertension: As monotherapy or in combination with other antihypertensive agents to lower elevated blood pressure and reduce cardiovascular risk

• Chronic stable angina pectoris: To prevent anginal attacks and improve exercise tolerance

• Supraventricular tachyarrhythmias: To control heart rate in conditions such as atrial fibrillation or atrial flutter

Dosage and Administration

• Adults: 60 mg orally, 2–3 times daily, depending on clinical response

• Dose may be adjusted by the physician based on blood pressure, heart rate, and tolerance

• Tablets can be taken with or without food

• Regular monitoring of blood pressure and heart rate is recommended during therapy

Contraindications

• Hypersensitivity to Diltiazem or other calcium channel blockers

• Severe hypotension (systolic BP < 90 mmHg)

• Acute myocardial infarction with pulmonary congestion

• Second- or third-degree AV block (without a pacemaker)

• Severe heart failure or cardiogenic shock

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Side Effects

Litizem Tablet 60 mg is generally well tolerated. Common side effects include:

• Headache, dizziness, flushing

• Gastrointestinal disturbances: nausea, constipation

• Peripheral edema, especially in the lower limbs

• Bradycardia or mild hypotension in sensitive patients

Rare but serious adverse effects may include:

• Severe hypotension

• Worsening heart failure

• AV block or conduction disturbances

Precautions and Warnings

• Use cautiously in patients with heart failure, liver dysfunction, or low blood pressure

• Monitor for signs of heart block or bradycardia

• Avoid abrupt discontinuation to prevent rebound angina

• Dose adjustment may be necessary in patients with hepatic impairment

Pregnancy and Lactation

• Use only if clearly needed; animal studies suggest no major teratogenic effects

• Excreted in breast milk; caution should be exercised during nursing

Storage Conditions

Store in a cool, dry place below 30°C, protected from light and moisture. Keep out of reach of children.