Afaz Tablet 40 mg contains the active ingredient Afatinib in the form of afatinib dimaleate. It is a targeted anticancer medication primarily used for the treatment of certain types of lung cancer. Afaz belongs to a class of medicines known as tyrosine kinase inhibitors (TKIs), which work by blocking specific proteins that promote the growth and spread of cancer cells. This medicine is commonly prescribed for patients diagnosed with Non‑Small Cell Lung Cancer, particularly those whose tumors carry specific epidermal growth factor receptor (EGFR) mutations.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Introduction

Afaz Tablet 40 mg is an oral anticancer therapy designed to slow or stop the growth of cancer cells in the body. Lung cancer is one of the most common and serious cancers worldwide, and targeted therapies such as afatinib have significantly improved treatment outcomes for patients with certain genetic mutations. Unlike traditional chemotherapy, afatinib specifically targets cancer-related pathways, which can lead to more effective treatment with fewer effects on normal cells.

Afaz is usually prescribed for patients with metastatic or advanced non-small cell lung cancer that has specific EGFR mutations. By interfering with the signaling pathways responsible for cancer cell growth, the medication helps control disease progression and may improve survival rates.

Composition

Each film-coated tablet contains:

• Afatinib Dimaleate equivalent to Afatinib 40 mg.

Mechanism of Action

Afatinib works by irreversibly blocking the ErbB family of receptors, including the epidermal growth factor receptor (EGFR). These receptors play a key role in regulating cell growth and division. In some cancers, EGFR becomes overactive due to genetic mutations, leading to uncontrolled cell proliferation.

Afatinib binds to these receptors and inhibits their activity, preventing the signaling that drives tumor growth and spread. By blocking multiple ErbB family receptors, afatinib helps slow the progression of cancer and may reduce tumor size.

Indications (Uses)

Afaz Tablet 40 mg is commonly indicated for:

• First-line treatment of metastatic Non‑Small Cell Lung Cancer with EGFR mutations

• Treatment of locally advanced or metastatic lung cancer that has progressed after other therapies

• Certain cases of squamous cell carcinoma of the lung after platinum-based chemotherapy

Treatment is typically guided by molecular testing to identify patients who are most likely to benefit from EGFR-targeted therapy.

Dosage and Administration

Afaz Tablet should be taken strictly according to a doctor’s prescription.

General guidance includes:

• The usual recommended dose is 40 mg once daily.

• The tablet should be taken on an empty stomach, at least 1 hour before or 2 hours after food.

• Tablets should be swallowed whole with water and not crushed or chewed.

Dose adjustments may be required depending on patient tolerance and side effects.

Benefits of Afaz Tablet

Afaz provides several therapeutic advantages in targeted cancer therapy:

• Specifically targets cancer cells with EGFR mutations

• Helps slow tumor growth and disease progression

• Oral tablet form allows convenient administration

• May improve survival and quality of life in eligible patients

• Provides an alternative to traditional chemotherapy in selected cases

Possible Side Effects

Like many anticancer medicines, Afaz may cause side effects. Common ones include:

• Diarrhea

• Skin rash or acne-like eruptions

• Mouth sores (stomatitis)

• Dry skin

• Decreased appetite

• Fatigue

Serious side effects, though less common, may include severe diarrhea, lung inflammation, liver problems, or eye disorders. Patients should contact their doctor immediately if severe symptoms occur.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Precautions and Warnings

• Liver and kidney function should be monitored during treatment.

• Patients with existing lung disease should use the medicine with caution.

• Pregnant women should avoid this medication as it may harm the unborn baby.

• Effective contraception should be used during treatment and for some time after therapy.

Storage Instructions

• Store below 30°C in a cool and dry place.

• Protect from moisture and direct sunlight.

• Keep out of reach of children.