Itrazen SB Capsule 65 mg contains Itraconazole, a broad-spectrum antifungal medication used for the treatment of various fungal infections affecting the skin, nails, respiratory tract, and internal organs. The “SB” formulation is designed for improved patient convenience and effective management of mild to moderate fungal infections, especially where dose adjustment or step-down therapy is required.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

Each capsule contains:

• Itraconazole 65 mg

Mechanism of Action

Itraconazole works by inhibiting the fungal enzyme lanosterol 14-α-demethylase, which is essential for the synthesis of ergosterol. Ergosterol is a key structural component of fungal cell membranes. By blocking its production, Itraconazole disrupts membrane integrity, leading to inhibition of fungal growth and eventual cell death.

Indications

Itrazen SB Capsule 65 mg is indicated for:

• Dermatophytosis (ringworm infections)
• Onychomycosis (fungal nail infections)
• Oral and esophageal candidiasis
• Superficial fungal skin infections
• Maintenance or step-down therapy after higher-dose antifungal treatment
• Mild to moderate fungal infections as prescribed by a physician

Dosage and Administration

• To be taken orally as directed by a physician
• Usually taken after meals for better absorption
• Dosage depends on infection type, severity, and patient response
• Capsules should be swallowed whole with water
• Complete the full prescribed course even if symptoms improve early

Contraindications

Itrazen SB Capsule should not be used in:

• Known hypersensitivity to Itraconazole
• Severe heart failure
• Severe liver disease without medical supervision
• Concomitant use with contraindicated CYP3A4-metabolized drugs

Side Effects

Possible side effects include:

• Nausea and vomiting
• Abdominal discomfort
• Headache
• Dizziness
• Skin rash
• Elevated liver enzymes

Serious side effects may include:

• Hepatotoxicity
• Worsening heart failure (rare but serious)

Precautions

• Liver function should be monitored during prolonged therapy
• Use cautiously in patients with cardiac disease
• Avoid alcohol to reduce liver toxicity risk
• Take after meals to improve absorption
• Not recommended during pregnancy unless clearly advised by a physician

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Drug Interactions

Itrazen SB Capsule may interact with:

• CYP3A4 substrate medications (significant interactions)
• Statins
• Anticoagulants
• Antiarrhythmic drugs
• Certain sedatives and benzodiazepines

Storage Conditions

• Store below 30°C in a dry place
• Protect from light and moisture
• Keep out of reach of children.