Paloxi Injection 0.25 mg/5 ml contains Palonosetron, a potent second-generation serotonin (5-HT3) receptor antagonist used to prevent nausea and vomiting associated with chemotherapy, radiotherapy, and surgical procedures. It provides both acute and delayed antiemetic control with a longer duration of action compared to first-generation agents.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

• Active Ingredient: Palonosetron Hydrochloride
• Strength: 0.25 mg per 5 ml

Mechanism of Action

Palonosetron selectively blocks 5-HT3 receptors located in the central nervous system and gastrointestinal tract. These receptors are responsible for triggering nausea and vomiting when stimulated by chemotherapeutic agents or surgical stress. By inhibiting this receptor pathway, Palonosetron effectively prevents both immediate and delayed emesis.

Indications

Paloxi Injection is indicated for:

• Prevention of chemotherapy-induced nausea and vomiting (CINV)
• Prevention of postoperative nausea and vomiting (PONV)
• Supportive care in radiotherapy-induced nausea and vomiting

Dosage and Administration

• Administered intravenously by a qualified healthcare professional only
• Given prior to chemotherapy or surgical procedures as per clinical protocol
• Dosage depends on patient condition and treatment regimen
• Not intended for self-administration

Benefits

• Provides long-lasting protection against nausea and vomiting
• Effective for both acute and delayed phases of chemotherapy-induced emesis
• Improves patient comfort and treatment adherence
• Reduces need for additional antiemetic medications

Possible Side Effects

Common side effects may include:

• Headache
• Constipation
• Dizziness
• Fatigue
• Mild injection site reactions

Serious hypersensitivity reactions are rare but may occur.

Precautions and Warnings

• Must be used under medical supervision only
• Use cautiously in patients with cardiac rhythm disorders
• Inform healthcare provider about all current medications
• Dose adjustment may be required in severe hepatic impairment
• Not intended for routine or unsupervised use

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Storage

• Store in a cool and dry place
• Protect from light
• Do not freeze
• Keep out of reach of children

Conclusion

Paloxi Injection 0.25 mg/5 ml (Palonosetron) is an effective antiemetic used for the prevention of nausea and vomiting caused by chemotherapy, radiotherapy, and surgery. It provides reliable and long-lasting symptom control when administered under proper medical supervision.