Glicana Tablet 100 mg is an oral antidiabetic medication containing Canagliflozin Hemihydrate, a selective sodium-glucose co-transporter 2 (SGLT2) inhibitor. It is designed to improve glycemic control in adults with type 2 diabetes mellitus (T2DM) by promoting glucose excretion through the urine. Glicana 100 mg offers a novel insulin-independent mechanism to lower blood glucose levels and is often used as monotherapy or in combination with other antidiabetic agents, such as metformin, sulfonylureas, or insulin, to achieve optimal glycemic control.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Indications

Glicana Tablet 100 mg is indicated for the management of:

• Type 2 diabetes mellitus (T2DM) in adults

• As monotherapy in patients who are intolerant to or inadequately controlled by diet and exercise alone

• Combination therapy with other antihyperglycemic agents when monotherapy does not achieve adequate glycemic control

• Reduction of the risk of cardiovascular events in adults with T2DM and established cardiovascular disease

This therapy is suitable for patients seeking effective glucose lowering with added benefits such as weight reduction and blood pressure improvement.

Therapeutic Class

• Sodium-Glucose Co-Transporter 2 (SGLT2) Inhibitor

• Antidiabetic Agent

Pharmacology

Canagliflozin works by inhibiting SGLT2 in the proximal renal tubules, reducing glucose reabsorption in the kidneys. This mechanism leads to increased urinary glucose excretion, decreased plasma glucose levels, and improved glycemic control. The effect is insulin-independent, making it effective even in patients with insulin resistance.

Additional benefits include modest reductions in body weight and systolic blood pressure, likely due to calorie loss from glycosuria and mild osmotic diuresis. Canagliflozin has minimal impact on hypoglycemia when used as monotherapy, but the risk may increase when combined with insulin or insulin secretagogues.

Dosage and Administration

• Recommended dose: 100 mg orally once daily, taken before the first meal of the day

• Dose may be increased to 300 mg once daily based on patient response and tolerability

• Swallow the tablet whole with water; do not crush or chew

Dosage adjustments may be required in patients with renal impairment. Regular monitoring of renal function, blood glucose, and HbA1c is advised during therapy.

Drug Interactions

• May interact with diuretics, increasing the risk of volume depletion

• Concomitant use with insulin or insulin secretagogues may increase hypoglycemia risk

• Minimal interaction with most other oral medications due to limited metabolism via CYP3A4

Contraindications

• Type 1 diabetes mellitus

• Severe renal impairment or end-stage renal disease

• History of hypersensitivity to canagliflozin or any component of the tablet

• Pregnancy and lactation

Side Effects

Common side effects may include:

• Genital mycotic infections (e.g., yeast infections)

• Urinary tract infections

• Increased urination (polyuria)

• Hypotension or dizziness due to volume depletion

• Nausea, constipation, or diarrhea

Rare but serious adverse effects:

• Ketoacidosis

• Acute kidney injury

• Bone fractures

• Lower limb amputation risk in high-risk patients

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Precautions and Warnings

• Ensure adequate hydration to reduce the risk of hypotension

• Monitor renal function periodically, especially in elderly patients or those on diuretics

• Educate patients on signs of urinary or genital infections

• Discontinue in cases of severe renal impairment or ketoacidosis

Pregnancy and Lactation

• Not recommended during pregnancy or breastfeeding

• Use effective contraception during treatment in women of reproductive potential

Storage Conditions

• Store at 20–25°C in a dry place

• Protect from moisture and light

• Keep out of reach of children.