Zomitan 2.5 mg is an effective antimigraine agent indicated for the acute treatment of migraine attacks in adults, with or without aura. Designed to provide rapid relief, it acts on specific serotonin receptors to reduce headache pain, associated neurological symptoms, and neurogenic inflammation. Zomitan is not intended for migraine prophylaxis but is highly effective when administered at the onset of an attack.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Therapeutic Class

5-HT Agonists

Indications

Zomitan 2.5 mg is specifically prescribed for:

• Acute migraine attacks in adults, with or without aura.

It is not indicated for prevention of migraine.

Pharmacology

Zomitan 2.5 mg is a selective 5-HT1B/1D receptor agonist. It binds with high affinity to serotonin receptors in cranial blood vessels and trigeminal sensory nerves, producing:

• Cranial vasoconstriction – reduces dilated blood vessels contributing to migraine pain

• Inhibition of neuropeptide release – prevents inflammation in the trigeminovascular system

Oral administration leads to rapid absorption and effective symptom relief, often within 1 hour of dosing.

Dosage and Administration

• Standard dose: 2.5 mg at the onset of a migraine attack

• Repeat dose: A second 2.5 mg dose may be administered if symptoms persist or recur within 24 hours, but no sooner than 2 hours after the first dose

• Escalation: Patients not responding to 2.5 mg may use a 5 mg dose for subsequent attacks

• Maximum daily dose: 10 mg within 24 hours

Administration tips:

• Take Zomitan tablets as early as possible after migraine onset for optimal results.

• Swallow tablets with water; no special dietary restrictions required.

Drug Interactions

• Avoid concomitant use of other 5-HT1B/1D agonists within 12 hours of Zomitan

• Ergotamine: wait 24 hours after ergotamine use before Zomitan; wait 6 hours after Zomitan before ergotamine use

• MAO inhibitors or general P450 inhibitors: maximum daily Zomitan dose 5 mg

• SSRIs (fluoxetine, sertraline, paroxetine, citalopram) do not significantly alter Zomitan pharmacokinetics

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Contraindications

Zomitan 2.5 mg should not be used in patients with:

• Known hypersensitivity to the drug

• Uncontrolled hypertension

• Ischaemic heart disease or coronary vasospasm (Prinzmetal’s angina)

• History of cerebrovascular accident (CVA) or transient ischaemic attack (TIA)

Side Effects

Zomitan 2.5 mg is generally well tolerated. Common adverse effects include:

• Nausea, dizziness, somnolence

• Warm sensation, fatigue (asthenia), dry mouth

• Transient sensory disturbances: tightness or pressure in chest, throat, neck, or limbs; muscle weakness, paraesthesia, or dysesthesia

Most side effects are mild, short-lived, and resolve without additional treatment.

Pregnancy and Lactation

• Pregnancy: Use only if benefits justify potential risk to the fetus

• Lactation: Caution is advised; Zomitan passes into milk in animal studies

Precautions & Warnings

• Confirm migraine diagnosis before use; exclude serious neurological conditions

• Not recommended for hemiplegic or basilar migraine

• Cardiovascular evaluation recommended in patients with potential coronary artery disease

• May cause mild transient increases in blood pressure, more pronounced in the elderly

Use in Special Populations

• Children: Safety and efficacy not established

• Patients >65 years: Limited clinical evaluation available

• Hepatic impairment: Reduce dose; maximum 5 mg in 24 hours

• Renal impairment: No dose adjustment needed

Storage

Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.