I-Penam 1 gm/vial contains Meropenem, a broad-spectrum carbapenem antibiotic intended for parenteral administration. It is used in the treatment of a wide range of serious bacterial infections caused by susceptible organisms in both adults and children. Due to its strong bactericidal activity and stability against most beta-lactamases, Meropenem is often reserved for severe or resistant infections.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Therapeutic Class

Other Beta-lactam Antibiotics

Indications

I-Penam 1 gm/vial is indicated for the treatment of infections caused by single or multiple bacteria sensitive to Meropenem, including:

• Pneumonia and nosocomial pneumonia

• Urinary tract infections

• Intra-abdominal infections

• Gynecological infections such as endometritis and pelvic inflammatory disease

• Skin and skin structure infections

• Meningitis

• Septicaemia

• Pulmonary infections in cystic fibrosis

• Empiric treatment of presumed infections in patients with febrile neutropenia

Pharmacology / Mode of Action

Meropenem is a carbapenem antibiotic that exerts its bactericidal effect by inhibiting bacterial cell wall synthesis. It penetrates bacterial cell walls efficiently and binds with high affinity to penicillin-binding proteins (PBPs). Meropenem demonstrates high stability against serine beta-lactamases and is active against a broad spectrum of Gram-positive and Gram-negative, aerobic and anaerobic bacteria.

Dosage and Administration

The dosage and duration depend on the type and severity of infection and the patient’s condition.

Adults:

• Usual dose: 500 mg to 1 g IV every 8 hours

• Severe infections (nosocomial pneumonia, septicaemia, neutropenic infections): 1 g IV every 8 hours

• Meningitis: 2 g IV every 8 hours

• Cystic fibrosis: Up to 2 g IV every 8 hours

Children:

• 3 months to 12 years: 10–40 mg/kg IV every 8 hours

• Meningitis: 40 mg/kg IV every 8 hours

• Children over 50 kg: Adult dosage

Meropenem may be administered by intravenous infusion over 15–30 minutes or as an intravenous bolus over 3–5 minutes.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Drug Interactions

• Probenecid may increase plasma levels of Meropenem by reducing renal excretion.

• Meropenem may reduce serum valproic acid levels, potentially leading to sub-therapeutic concentrations.

Contraindications

Contraindicated in patients with known hypersensitivity to Meropenem or other beta-lactam antibiotics.

Side Effects

Generally well tolerated. Possible adverse effects include injection site reactions, rash, pruritus, gastrointestinal disturbances, headache, and thrombophlebitis.

Pregnancy and Lactation

Pregnancy Category B. Use during pregnancy only if clearly needed. Caution is advised during breastfeeding as Meropenem may be excreted in breast milk.

Precautions and Warnings

Discontinue immediately if allergic reactions occur. Liver function should be monitored in patients with hepatic disease. Dosage adjustment is required in renal impairment.

Storage Conditions

Store below 30°C in a cool, dry place, protected from light and moisture. Keep out of reach of children.