Venclax Tablet 100 mg contains Venetoclax, a targeted anticancer medicine belonging to the BCL-2 inhibitor class. It is used in the treatment of certain blood cancers by restoring the natural process of programmed cell death (apoptosis) in malignant cells.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Indications

Venclax Tablet is indicated for:

• Chronic lymphocytic leukemia (CLL)
• Small lymphocytic lymphoma (SLL)
• Acute myeloid leukemia (AML) in combination therapy (as per oncology protocols)
• Other hematologic malignancies as directed by an oncologist

Mechanism of Action

Venetoclax selectively inhibits the BCL-2 protein, which helps cancer cells avoid apoptosis. By blocking this protein, it:

• Restores programmed cell death in cancer cells
• Reduces survival of malignant lymphocytes
• Helps shrink tumor burden
• Improves disease control in blood cancers

Dosage and Administration

• Taken orally once daily under oncologist supervision
• Dose is gradually increased using a step-up dosing schedule
• Should be taken with food and water at the same time each day
• Tablets must be swallowed whole, not crushed or chewed
• Close monitoring is required during initiation phase

Benefits

• Targeted therapy for blood cancers
• Effective in reducing lymph node enlargement and abnormal blood counts
• Improves disease control in CLL/SLL and AML
• Oral administration for convenience
• Can be combined with other anticancer agents

Side Effects

Common side effects may include:

• Neutropenia (low white blood cells)
• Nausea
• Diarrhea
• Fatigue
• Upper respiratory tract infections

Serious side effects:

• Tumor lysis syndrome (TLS)
• Severe infections
• Anemia and thrombocytopenia
• Kidney impairment due to TLS

Precautions and Warnings

• Must be started under strict medical supervision
• High risk of tumor lysis syndrome—requires preventive measures and monitoring
• Regular blood tests are essential during treatment
• Use cautiously in patients with liver or kidney impairment
• Not recommended during pregnancy or breastfeeding
• Effective contraception is required during and after treatment

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Drug Interactions

Venclax Tablet may interact with:

• Strong CYP3A inhibitors (increase toxicity risk)
• Strong CYP3A inducers (reduce effectiveness)
• Azole antifungals
• Certain antibiotics and antiviral drugs

Dose adjustment may be necessary when used with interacting drugs.

Storage

• Store below 30°C in a dry place
• Protect from moisture and light
• Keep out of reach of children.