Covista Tablet combines Sacubitril 97 mg and Valsartan 103 mg in a potent formulation designed for the management of chronic heart failure with reduced ejection fraction (HFrEF). This medication belongs to the ARNI (Angiotensin Receptor-Neprilysin Inhibitor) class, providing dual action: Sacubitril enhances beneficial natriuretic peptides that promote vasodilation and sodium excretion, while Valsartan blocks angiotensin II receptors to reduce vasoconstriction and lower blood pressure. Together, Covista helps improve heart efficiency, relieve symptoms of heart failure, and reduce the risk of cardiovascular hospitalization and mortality.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Indications

Covista Tablet 97 mg + 103 mg is indicated for:

• Treatment of chronic heart failure with reduced ejection fraction (HFrEF)
• Reducing cardiovascular death and hospitalization in heart failure patients
• Patients who remain symptomatic despite standard therapy with ACE inhibitors or other heart failure medications

Mechanism of Action

• Sacubitril: Inhibits neprilysin, increasing levels of natriuretic peptides, which dilate blood vessels, promote sodium excretion, and reduce fluid retention.
• Valsartan: Blocks AT1 receptors for angiotensin II, preventing vasoconstriction, lowering blood pressure, and decreasing cardiac workload.
• Combined Effect: Enhances heart function, alleviates fluid overload, improves exercise tolerance, and reduces heart failure complications.

Dosage and Administration

• The usual dose is one tablet twice daily, or as prescribed by a physician
• Swallow the tablet whole with water
• Can be taken with or without food
• Regular monitoring of blood pressure, kidney function, and electrolytes is recommended
• Dose adjustments may be necessary for patients with renal or hepatic impairment

Benefits

• Improves symptoms of heart failure such as breathlessness, fatigue, and fluid retention
• Reduces the risk of hospitalization and cardiovascular death
• Enhances cardiac efficiency through dual action on neprilysin and angiotensin II pathways
• Convenient twice-daily dosing for long-term therapy
• Suitable for patients not adequately controlled on other standard therapies

Side Effects

Common side effects may include:

• Low blood pressure (hypotension)
• Dizziness or lightheadedness
• Elevated potassium levels (hyperkalemia)
• Mild cough

Rare but serious side effects:

• Kidney function impairment
• Angioedema (swelling of face, lips, tongue, or throat)
• Severe hypotension

Seek medical attention immediately if severe side effects or allergic reactions occur.

Precautions

• Do not use Covista with ACE inhibitors or within 36 hours of an ACE inhibitor dose
• Monitor renal function and serum electrolytes regularly
• Use with caution in patients with kidney or liver impairment
• Inform your doctor if pregnant, planning pregnancy, or breastfeeding
• Avoid abrupt discontinuation without medical supervision

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Use in Special Populations

• Pregnancy: Contraindicated; may cause fetal harm
• Lactation: Consult a physician before use
• Elderly: Monitor for hypotension and kidney function
• Renal or hepatic impairment: Dose adjustments required

Storage

• Store below 30°C
• Keep in a dry, cool place away from light
• Keep out of reach of children.