Tycil 250 mg contains Amoxicillin, a broad-spectrum penicillin antibiotic widely used for the treatment of various bacterial infections caused by susceptible, β-lactamase negative microorganisms. It works effectively against a wide range of Gram-positive and Gram-negative bacteria, making it a trusted option in everyday clinical practice.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Therapeutic Class

Broad Spectrum Penicillins

Pharmacology

Amoxicillin acts by inhibiting the biosynthesis of bacterial cell walls, leading to cell lysis and bacterial death. It is stable in the presence of gastric acid and is rapidly absorbed after oral administration. Peak plasma concentrations are typically achieved within 1 to 2 hours. Amoxicillin is widely distributed throughout body tissues and fluids, ensuring effective antibacterial activity at the site of infection.

Indications

Tycil 250 mg is indicated for the treatment of the following infections when caused by susceptible organisms:

• Ear, Nose, and Throat Infections: Otitis media, sinusitis, tonsillitis, pharyngitis, laryngitis

• Lower Respiratory Tract Infections: Pneumonia, acute and chronic bronchitis, lung abscess, empyema, bronchiectasis

• Skin and Soft Tissue Infections: Cellulitis, carbuncles, furunculosis, infected wounds, abscesses

• Genito-Urinary Tract Infections: Pyelonephritis, cystitis, urethritis

• Venereal Disease: Acute uncomplicated gonorrhoea

• Dental Infections: Short-term therapy for dental abscess

• Gastrointestinal Indication: In combination with clarithromycin and lansoprazole as part of triple therapy for Helicobacter pylori infection and duodenal ulcer disease, and to reduce the risk of ulcer recurrence

Dosage and Administration

Dosage should be adjusted according to the severity of infection and patient response.

• Adults:

  • Usual dose: 250 mg three times daily

  • Severe infections: Up to 500 mg three times daily

• Children (up to 10 years):

  • Usual dose: 125 mg three times daily

  • Severe infections: Up to 250 mg three times daily

• Special Dosage Recommendations:

  • Otitis media (adults): 1 g three times daily

  • Pneumonia: 500–1000 mg three times daily

  • Dental abscess or UTI: 3 g, repeated after 10–12 hours

  • Gonorrhoea: Single dose of 2–3 g with probenecid

Dose reduction may be required in patients with renal impairment.

Reconstituted suspension may be mixed with water, milk, or fruit juice and should be taken immediately after preparation.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Drug Interactions

• Probenecid may increase and prolong blood levels of amoxicillin

• May reduce the effectiveness of combined oral estrogen/progesterone contraceptives

Contraindications

Tycil 250 mg is contraindicated in patients with known hypersensitivity to penicillins.

Side Effects

Side effects are generally mild and transient and may include diarrhoea, indigestion, nausea, or skin rash. Rare cases of pseudomembranous colitis have been reported.

Pregnancy and Lactation

Amoxicillin is classified as US FDA Pregnancy Category B. It should be used during pregnancy only if clearly needed. As it is excreted in breast milk, caution is advised during lactation.

Precautions and Warnings

Prolonged use may result in superinfection with resistant organisms. Therapy should be discontinued if superinfection occurs and appropriate treatment initiated.

Storage Conditions

Store in a dry place away from light and heat. Keep out of the reach of children.