Irinox Injection 20 mg/ml contains Irinotecan Hydrochloride, a potent anticancer medication used in the treatment of colorectal cancer and other solid tumors. It belongs to the class of topoisomerase I inhibitors, which interfere with DNA replication in rapidly dividing cancer cells, leading to cell death.

This injection is administered in hospital settings under strict oncological supervision due to its strong cytotoxic effects.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

Each ml contains:

• Irinotecan Hydrochloride 20 mg

Mechanism of Action

Irinotecan is a prodrug that is converted in the body to its active metabolite SN-38. This active form inhibits the enzyme topoisomerase I, which is essential for DNA unwinding and replication. By blocking this enzyme, Irinotecan causes DNA damage in cancer cells, ultimately leading to apoptosis (cell death).

Indications

Irinox Injection 20 mg/ml is indicated for:

• Metastatic colorectal cancer
• Advanced pancreatic cancer (in combination therapy)
• Small cell lung cancer
• Other solid tumors as prescribed by an oncologist

Dosage and Administration

• Administered intravenously under medical supervision only
• Dosage is based on body surface area and treatment protocol
• Given as intermittent infusion, often in combination chemotherapy regimens
• Pre-medication may be required to reduce side effects
• Regular monitoring of blood counts is essential

Contraindications

Irinox Injection should not be used in:

• Known hypersensitivity to Irinotecan
• Severe bone marrow suppression
• Severe liver impairment
• Active uncontrolled infections
• Pregnancy and breastfeeding unless clearly advised

Side Effects

Common side effects include:

• Diarrhea (early and late onset)
• Nausea and vomiting
• Hair loss
• Loss of appetite
• Fatigue
• Abdominal cramps

Serious side effects may include:

• Severe diarrhea leading to dehydration
• Bone marrow suppression (neutropenia)
• Increased infection risk
• Liver toxicity

Precautions

• Monitor complete blood counts regularly
• Maintain adequate hydration during therapy
• Use anti-diarrheal treatment as prescribed
• Caution in patients with liver dysfunction
• Avoid infections due to immunosuppression

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Drug Interactions

Irinox Injection may interact with:

• CYP3A4 inhibitors or inducers (affect drug metabolism)
• Other myelosuppressive drugs
• Anticoagulants (may increase bleeding risk)
• Herbal supplements affecting liver enzymes

Storage Conditions

• Store below 25°C
• Protect from light
• Do not freeze
• Keep out of reach of children.