Amdocal Plus Tablet 5 mg+25 mg is a combination therapy containing amlodipine besilate 5 mg and atenolol 25 mg, designed for the management of hypertension and related cardiovascular conditions. By combining a calcium channel blocker (amlodipine) with a beta-adrenergic blocker (atenolol), Amdocal Plus provides a dual mechanism to effectively lower blood pressure, reduce cardiac workload, and prevent complications associated with high blood pressure. This combination is particularly useful in patients who require better blood pressure control than what monotherapy can provide.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Therapeutic Class

Antihypertensive / Calcium Channel Blocker + Beta-Blocker

Indications

Amdocal Plus Tablet 5 mg+25 mg is indicated for:

• Hypertension: For adults whose blood pressure is not adequately controlled with single-agent therapy.

• Angina Pectoris: Helps reduce the frequency and severity of angina attacks by improving oxygen delivery to the heart.

• Other Cardiovascular Conditions: May be used to prevent complications related to left ventricular hypertrophy, myocardial infarction, or heart failure as determined by the treating physician.

Pharmacology and Mode of Action

The two active ingredients in Amdocal Plus work synergistically to improve cardiovascular function:

Amlodipine Besilate:
Amlodipine is a dihydropyridine calcium channel blocker that inhibits calcium ion influx through L-type channels in vascular smooth muscle. This causes vasodilation, reduces peripheral vascular resistance, lowers blood pressure, and improves myocardial oxygen supply without significantly affecting heart rate.

Atenolol:
Atenolol is a selective beta-1 adrenergic blocker that reduces heart rate, cardiac output, and myocardial oxygen demand. By blocking beta-1 receptors, atenolol also inhibits renin release from the kidneys, contributing to blood pressure reduction.

Combined Effect:
The combination of amlodipine and atenolol offers complementary mechanisms: amlodipine relaxes blood vessels, while atenolol slows heart rate and decreases cardiac workload. This leads to more effective and sustained blood pressure control and improved management of angina.

Dosage and Administration

• Typical Adult Dose: One tablet once daily, preferably at the same time each day.

• Adjustment: Dosing may be individualized based on patient response, tolerability, and previous antihypertensive therapy.

• Administration: Tablets should be swallowed whole with water. They can be taken with or without food.

Patients should continue to monitor blood pressure regularly and adhere to lifestyle modifications such as reduced salt intake, exercise, and weight management.

Contraindications

Amdocal Plus Tablet 5 mg+25 mg is contraindicated in patients with:

• Severe bradycardia, heart block greater than first degree, or cardiogenic shock

• Severe hypotension

• Decompensated heart failure

• Known hypersensitivity to amlodipine, atenolol, or any excipient

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Side Effects

Common side effects include:

• Dizziness, headache, fatigue

• Peripheral edema (swelling of hands, feet, or ankles)

• Bradycardia (slow heart rate)

• Flushing or palpitations

Rare but serious effects may include hypotension, worsening heart failure, bronchospasm in susceptible patients, or allergic reactions.

Precautions and Warnings

• Use with caution in patients with diabetes, respiratory disorders, kidney or liver impairment, and elderly patients.

• Avoid abrupt discontinuation, especially of atenolol, to prevent rebound hypertension or angina exacerbation.

• Regular monitoring of blood pressure, heart rate, and renal function is recommended.

Pregnancy and Lactation

Amlodipine and atenolol should be used during pregnancy only if clearly necessary. Limited data are available on excretion into breast milk; caution is advised in nursing women.

Storage Conditions

Store in a cool, dry place below 30°C, protected from light and moisture. Keep out of reach of children.