Trexall Tablet 10 mg contains Methotrexate, an antimetabolite and immunosuppressant medicine used in the treatment of certain cancers, autoimmune disorders, and severe inflammatory conditions. It works by slowing down the growth of rapidly dividing cells and reducing abnormal immune system activity.

Methotrexate is widely used in oncology and rheumatology due to its proven effectiveness in controlling diseases such as rheumatoid arthritis, psoriasis, and certain cancers.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

Each tablet contains:

• Methotrexate 10 mg

Available as an oral tablet formulation.

Indications

Trexall Tablet 10 mg is indicated for:

• Rheumatoid arthritis (moderate to severe cases)
• Severe psoriasis and psoriatic arthritis
• Acute lymphoblastic leukemia (ALL)
• Non-Hodgkin lymphoma (as part of combination therapy)
• Breast cancer (in selected regimens)
• Other autoimmune and inflammatory disorders as prescribed by a physician

Mechanism of Action

Methotrexate works by inhibiting dihydrofolate reductase (DHFR), an enzyme required for DNA synthesis and cell replication. This reduces the production of new cells, especially rapidly dividing immune and cancer cells.

In autoimmune diseases, Methotrexate suppresses excessive immune activity, helping reduce inflammation, pain, and tissue damage.

Dosage and Administration

Trexall Tablet should be taken strictly under medical supervision.

General guidelines:

• Usually taken once weekly (not daily in most autoimmune conditions)
• Dose depends on disease condition and patient response
• May be taken with or without food
• Swallow with water; do not crush or chew

Folic acid supplementation may be prescribed to reduce side effects in long-term therapy.

Benefits of Trexall Tablet

• Effective in controlling rheumatoid arthritis symptoms
• Reduces joint inflammation and damage
• Helps manage severe psoriasis
• Plays a key role in cancer treatment regimens
• Slows disease progression in autoimmune conditions

Possible Side Effects

Common side effects may include:

• Nausea and vomiting
• Mouth ulcers
• Fatigue
• Loss of appetite
• Hair thinning
• Stomach discomfort

Serious side effects include:

• Liver toxicity
• Bone marrow suppression (low blood counts)
• Increased risk of infections
• Lung inflammation (rare but serious)

Precautions and Warnings

• Must not be used during pregnancy (risk of fetal harm)
• Regular blood tests (CBC, liver, kidney function) are essential
• Avoid alcohol to reduce risk of liver damage
• Use with caution in kidney or liver disease
• Do not take daily unless specifically prescribed for oncology use
• Inform the doctor about all medications being used

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Storage Instructions

• Store below 25°C
• Protect from moisture and light
• Keep out of reach of children
• Use only under prescription and supervision

Conclusion

Trexall Tablet 10 mg (Methotrexate) is a widely used immunosuppressant and anticancer medicine effective in treating rheumatoid arthritis, psoriasis, and certain malignancies. By reducing abnormal cell growth and immune activity, it helps control disease progression and improve patient outcomes. Careful medical supervision and regular monitoring are essential for safe and effective use.