Terbinafine is an allylamine antifungal agent with potent activity against a wide range of fungi. It works by inhibiting the enzyme squalene epoxidase, which is essential for fungal ergosterol biosynthesis. Ergosterol is a vital component of the fungal cell membrane. Inhibition of this pathway leads to ergosterol deficiency and intracellular accumulation of squalene, resulting in disruption of cell membrane integrity and fungal cell death.
Terbinafine is fungicidal against dermatophytes, molds, and certain dimorphic fungi, and may be fungicidal or fungistatic against yeasts depending on the species. Topical terbinafine has demonstrated high efficacy in infections of the skin caused by Trichophyton, Microsporum, Epidermophyton, and Candida species, as well as Malassezia furfur responsible for pityriasis versicolor.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Indications

Terbex Cream 1% is indicated for the treatment of:

• Tinea corporis (ringworm of the body)

• Tinea cruris (jock itch)

• Tinea pedis (athlete’s foot)

• Cutaneous candidiasis

• Pityriasis (tinea) versicolor

• Other superficial fungal infections of the skin caused by susceptible organisms

Dosage and Administration

• For topical use only

• Clean and dry the affected area thoroughly before application

• Apply a thin layer of Terbex Cream once or twice daily to the affected skin and surrounding area and rub in gently

Usual Duration of Treatment:

• Tinea corporis, Tinea cruris: 1–2 weeks

• Tinea pedis: 1–4 weeks (one week may be sufficient if applied twice daily)

• Cutaneous candidiasis: 1–2 weeks

• Pityriasis versicolor: 2 weeks

In intertriginous areas, the treated area may be covered with a gauze strip, especially at night. Treatment should be continued for the full recommended duration to prevent recurrence.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Contraindications

• Known hypersensitivity to terbinafine or any component of the formulation

Side Effects

Terbex Cream is generally well tolerated. Possible side effects include:

• Mild burning sensation

• Itching or redness at the application site

• Skin rash or irritation

These reactions are usually mild, transient, and resolve without discontinuation.

Warnings and Precautions

• For external use only

• Avoid contact with eyes and mucous membranes

• If irritation or allergic reaction occurs, discontinue use

• If there is no improvement after two weeks, the diagnosis should be reassessed

Use in Pregnancy and Lactation

Animal studies have shown no evidence of fetal harm. However, due to limited clinical data, terbinafine cream should be used during pregnancy only if the potential benefit justifies the potential risk. Terbinafine is excreted in breast milk; therefore, breastfeeding mothers should avoid use unless advised by a healthcare professional.

Use in Special Populations

• Children: Appears to be effective and well tolerated in tinea corporis and tinea cruris

• Elderly: No dosage adjustment is usually required

Storage Conditions

• Store below 30°C

• Keep in a cool and dry place

• Protect from light

• Keep out of reach of children.