Amlodipine Besilate inhibits the influx of calcium ions into vascular smooth muscle and myocardial cells. This leads to relaxation of peripheral arteries, reduced systemic vascular resistance, and gradual lowering of blood pressure without significant reflex tachycardia. Its long duration of action supports stable 24-hour blood pressure control.
Telmisartan selectively blocks the binding of angiotensin II to the AT1 receptor in vascular smooth muscle and adrenal glands. Angiotensin II normally causes vasoconstriction and aldosterone secretion, resulting in sodium and water retention. By inhibiting these effects, telmisartan promotes vasodilation, reduces blood volume, and lowers blood pressure.
Together, amlodipine and telmisartan provide an additive and complementary antihypertensive effect, improving blood pressure control compared to either agent alone.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Indications

Telmacal Tablet 10 mg + 80 mg is indicated for:

• Treatment of essential hypertension in adults

• Patients whose blood pressure is not adequately controlled with amlodipine, telmisartan, or lower-dose combination therapy

• Patients requiring high-dose combination therapy for optimal blood pressure management

Dosage and Administration

• Dosage should be individualized according to patient response and clinical condition

• The usual recommended dose is one tablet once daily

• Tablets may be taken with or without food

• Blood pressure should be monitored regularly during treatment

• Dose adjustment may be required in elderly patients or those with hepatic impairment

Contraindications

• Hypersensitivity to amlodipine, telmisartan, or any component of the formulation

• Pregnancy and lactation

• Severe hepatic impairment or biliary obstructive disorders

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Warnings and Precautions

• Hypotension may occur, particularly in patients with volume or sodium depletion

• Peripheral edema may occur due to amlodipine, especially at higher doses

• Use with caution in patients with renal or hepatic impairment

• Avoid concomitant use with other drugs affecting the renin-angiotensin system unless clearly indicated

Side Effects

Commonly reported side effects include:

• Dizziness or headache

• Peripheral edema

• Flushing

• Fatigue

• Hypotension

Most adverse effects are mild to moderate and tend to resolve with continued therapy or dose adjustment.

Drug Interactions

• Other antihypertensive agents may enhance blood pressure-lowering effects

• NSAIDs may reduce antihypertensive efficacy and impair renal function

• Potassium supplements or potassium-sparing diuretics should be used cautiously

Pregnancy and Lactation

• Telmacal Tablet is contraindicated during pregnancy due to the risk of fetal harm

• Breastfeeding should be discontinued during therapy

Storage Conditions

• Store below 30°C in a cool and dry place

• Protect from light and moisture

• Keep out of reach of children

Presentation

Telmacal Tablet 10 mg + 80 mg is available in blister packs, ensuring product stability and convenient once-daily dosing.