Tacrograf Capsule 1 mg contains Tacrolimus Monohydrate, a powerful immunosuppressant medication used to prevent organ rejection in patients who have undergone organ transplantation. It is commonly prescribed in kidney, liver, and heart transplant recipients as part of a long-term immunosuppressive regimen. Tacrolimus helps protect the transplanted organ by suppressing the body’s immune response.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

• Active Ingredient: Tacrolimus Monohydrate 1 mg

Mechanism of Action

Tacrolimus works by inhibiting the enzyme calcineurin in T-lymphocytes (T-cells). This blocks the activation of T-cells and reduces the production of interleukin-2 (IL-2), a key cytokine responsible for immune response activation. As a result, the immune system’s ability to attack the transplanted organ is reduced, helping prevent rejection.

Indications

Tacrograf Capsule 1 mg is indicated for:

• Prevention of kidney transplant rejection
• Prevention of liver transplant rejection
• Prevention of heart transplant rejection (as part of combination therapy)
• Other organ transplant immunosuppression protocols as directed by a specialist

Dosage and Administration

• Dosage is strictly individualized and must be determined by a transplant specialist.
• Usually taken twice daily at consistent time intervals.
• Should be taken regularly at the same time each day for stable blood levels.
• Can be taken with or without food, but consistency is important.
• Regular monitoring of blood drug levels is essential to ensure safety and effectiveness.

Benefits

• Helps prevent rejection of transplanted organs
• Effective long-term immunosuppressive therapy
• Can be used in combination with other immunosuppressants
• Improves transplant survival outcomes
• Oral capsule provides convenient administration

Side Effects

Common side effects may include:

• Tremors
• Headache
• Nausea or vomiting
• Increased blood pressure
• Elevated blood sugar levels
• Kidney function changes

Serious side effects may include infections due to reduced immunity, kidney toxicity, neurological effects, or electrolyte imbalance. Immediate medical attention is required if severe symptoms occur.

Precautions and Warnings

• Must be used only under strict supervision of a transplant specialist.
• Regular monitoring of kidney function, blood pressure, and drug levels is essential.
• Increased risk of infections due to immune suppression.
• Avoid live vaccines during treatment.
• Use cautiously in patients with liver or kidney impairment.
• Inform your doctor if you are pregnant or breastfeeding.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Drug Interactions

Tacrograf Capsule may interact with:

• CYP3A4 inhibitors (e.g., ketoconazole, erythromycin)
• CYP3A4 inducers (e.g., rifampin, phenytoin, carbamazepine)
• Other immunosuppressants
• Certain antihypertensives and antifungal agents
• Grapefruit juice (may increase drug levels)

Always inform your healthcare provider about all medications and supplements.

Storage

• Store below 25–30°C in a cool, dry place
• Protect from light and moisture
• Keep out of reach of children.