Metalyse Injection 5 mg/ml contains Tenecteplase, a genetically engineered thrombolytic (clot-dissolving) agent used in emergency cardiac care. It is specifically formulated for the rapid treatment of acute ST-elevation myocardial infarction (STEMI), commonly known as a severe heart attack.

Tenecteplase is a modified form of tissue plasminogen activator (tPA) that works by binding to fibrin within a blood clot and converting plasminogen to plasmin. Plasmin then breaks down fibrin, effectively dissolving the clot and restoring blood flow to the affected coronary artery. Early administration significantly improves survival and reduces heart muscle damage.

   রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Key Benefits

• Rapid clot dissolution
  Effectively dissolves blood clots blocking coronary arteries during acute myocardial infarction.

• Single bolus administration
  Given as a single intravenous bolus over 5 seconds, allowing quick and convenient emergency use.

• Improved fibrin specificity
  Targets fibrin-rich clots with enhanced selectivity, minimizing systemic effects.

• Reduced myocardial damage
  Helps restore blood flow promptly, limiting heart muscle injury and improving clinical outcomes.

Indications

Metalyse Injection is indicated for:

• Thrombolytic treatment of acute ST-elevation myocardial infarction (STEMI) in adults within the appropriate therapeutic time window after symptom onset.

Treatment should be initiated as soon as possible after the onset of heart attack symptoms, ideally within 6 hours.

   রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Dosage and Administration

• Administered as a single intravenous bolus injection.

• The dose is weight-based and determined by the patient’s body weight.

• Should be administered by experienced healthcare professionals in a hospital setting equipped for cardiac emergency management.

• Concomitant therapy with anticoagulants and antiplatelet agents may be recommended as per standard clinical guidelines.

Mechanism of Action

Tenecteplase is a recombinant fibrin-specific plasminogen activator. It binds to fibrin within a thrombus and converts plasminogen to plasmin, which degrades the fibrin matrix of the clot. This process restores blood flow in occluded coronary arteries.

Safety Information

Contraindications include:

• Active internal bleeding

• History of hemorrhagic stroke

• Recent major surgery or trauma

• Severe uncontrolled hypertension

Warnings and precautions:

• Increased risk of bleeding, including intracranial hemorrhage

• Careful patient selection is essential

• Continuous monitoring during and after administration is required

Use in pregnancy and lactation should be considered only if clearly necessary and under medical supervision.

Storage

Store according to manufacturer instructions. Protect from light and maintain recommended storage temperature. Keep out of reach of children.