Sodival CR Tablet 500 mg contains Sodium Valproate, a broad-spectrum anticonvulsant and mood stabilizer used to manage epilepsy, bipolar disorder, and seizure-related conditions. The controlled-release (CR) formulation ensures a gradual and sustained release of the active ingredient, maintaining steady plasma levels for improved seizure control and mood stabilization.

This higher-strength formulation is ideal for patients who require long-term, once or twice-daily dosing, offering enhanced compliance, consistent therapeutic effect, and minimized side effects.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

• Sodium Valproate 500 mg per controlled-release tablet

Mechanism of Action

• Sodium Valproate enhances gamma-aminobutyric acid (GABA) activity, an inhibitory neurotransmitter in the central nervous system, which reduces excessive neuronal firing.
• Helps prevent the propagation of seizures and stabilizes neuronal excitability.
• Modulates neurotransmitter activity involved in mood regulation, supporting the treatment of mania and mood swings in bipolar disorder.
• The CR formulation maintains stable blood levels, reducing peak-related side effects and improving tolerability.

Indications

Sodival CR Tablet 500 mg is indicated for:

• Epilepsy: generalized, partial, and mixed seizure types
• Bipolar disorder: treatment and prophylaxis of manic and mixed episodes
• Migraine prophylaxis (off-label, as per physician discretion)
• Other neurological disorders benefiting from GABAergic modulation

Dosage & Administration

• Take as prescribed by a physician
• Swallow the tablet whole with water, preferably after meals to reduce gastrointestinal irritation
• Adults may start with 500 mg once or twice daily, adjusted based on clinical response and serum levels
• Dose adjustments are necessary for children, elderly, or patients with liver impairment
• Do not crush or chew the CR tablet to maintain controlled-release properties

Benefits

• Reduces frequency and severity of seizures
• Stabilizes mood swings in bipolar disorder
• Controlled-release formulation ensures consistent therapeutic effect
• Convenient once or twice-daily dosing improves compliance
• Supports long-term neurological and psychiatric health

Possible Side Effects

Common side effects:

• Nausea, vomiting, or mild gastrointestinal discomfort
• Drowsiness, dizziness, or tremors
• Weight gain or increased appetite
• Temporary hair thinning

Serious but rare side effects:

• Liver toxicity (hepatitis, elevated liver enzymes)
• Pancreatitis
• Severe allergic reactions (rash, swelling, difficulty breathing)
• Blood disorders such as thrombocytopenia or leukopenia

Precautions & Warnings

• Regular liver function tests and blood counts are recommended during therapy
• Avoid in patients with known liver disease or urea cycle disorders
• Not recommended in pregnancy, unless strictly necessary, due to risk of fetal malformations
• Do not abruptly discontinue to prevent seizure recurrence
• Inform the physician about all concomitant medications to avoid interactions

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Storage

• Store at 20–25°C in a dry, cool place
• Keep the tablet in its original container, protected from moisture and light
• Keep out of reach of children

Conclusion

Sodival CR Tablet 500 mg (Sodium Valproate) is a high-strength controlled-release anticonvulsant and mood stabilizer. It effectively manages epilepsy and bipolar disorder, offering consistent blood levels, improved compliance, and long-term protection against seizures and mood instability.