Hepaclin Tablet 150 mg contains L-Ornithine L-Aspartate (LOLA), a clinically proven amino acid compound used for supporting liver function and managing conditions associated with hyperammonemia. It is commonly prescribed in the treatment of hepatic encephalopathy, liver cirrhosis, and other chronic liver diseases where elevated ammonia levels can lead to neurological complications. Hepaclin works by enhancing the liver’s natural ability to detoxify ammonia and improve nitrogen metabolism, supporting overall liver health.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Indications

Hepaclin Tablet 150 mg is indicated for:

• Management of hyperammonemia in patients with chronic liver disease

• Hepatic encephalopathy and prevention of recurrence in liver cirrhosis

• Supportive therapy for patients with compromised liver function to reduce toxic effects of ammonia accumulation

• Adjunct therapy in conditions associated with elevated blood ammonia levels

It is suitable for adult patients requiring improved detoxification of nitrogenous waste due to impaired liver function.

Therapeutic Class

• Amino Acid Supplement

• Liver Support Agent

Pharmacology

L-Ornithine L-Aspartate is a combination of the amino acids ornithine and aspartate, which play a key role in the urea cycle.

• Ornithine stimulates the urea cycle in the liver, enhancing the conversion of ammonia into urea, which is then excreted via the kidneys.

• Aspartate contributes to glutamate synthesis, supporting detoxification and reducing blood ammonia levels.

Through these mechanisms, Hepaclin reduces the neurotoxic effects of ammonia, improving mental alertness, reducing confusion, and alleviating symptoms of hepatic encephalopathy. Unlike other medications, LOLA works by enhancing natural metabolic pathways, rather than suppressing ammonia production.

Dosage and Administration

• The usual adult dose is 150 mg per tablet, taken 2–3 times daily or as prescribed by the physician

• Tablets should be swallowed whole with water

• Dosage may be adjusted based on the severity of liver dysfunction and plasma ammonia levels

• Long-term use should be guided by a healthcare professional with periodic monitoring of liver function tests and ammonia levels

Hepaclin is most effective when combined with a liver-friendly diet and supportive therapy for liver disease.

Drug Interactions

• No significant interactions have been reported

• Caution is advised when used alongside other liver-active medications; monitoring liver enzymes may be necessary

• Inform the physician of all concurrent medications

Contraindications

• Hypersensitivity to L-Ornithine, L-Aspartate, or any component of the tablet

• Severe renal impairment without medical supervision

• Not recommended for children unless specifically prescribed

Side Effects

Hepaclin is generally well tolerated. Rare and mild side effects may include:

• Gastrointestinal disturbances such as nausea, bloating, or mild diarrhea

• Occasional headache or dizziness

• Rare allergic reactions

Most side effects are transient and resolve without discontinuation of therapy.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Precautions and Warnings

• Use caution in patients with renal impairment, as the excretion of urea may be affected

• Monitor plasma ammonia levels and liver function periodically

• Not a substitute for proper medical management of underlying liver disease

• Consult a healthcare provider if symptoms worsen or persist

Pregnancy and Lactation

• Safety in pregnancy and lactation has not been fully established; use only if clearly needed and prescribed by a physician

Storage Conditions

• Store at 20–25°C in a dry place

• Protect from moisture and light

• Keep out of reach of children.