Sliptin Tablet 100 mg contains Sitagliptin, a highly effective oral antihyperglycemic agent from the class of Dipeptidyl Peptidase-4 (DPP-4) inhibitors, indicated for the management of type 2 diabetes mellitus in adults. Sitagliptin works by enhancing the body’s natural incretin system, which regulates glucose levels by stimulating insulin release and suppressing glucagon secretion in a glucose-dependent manner. This helps reduce elevated blood sugar levels while minimizing the risk of hypoglycemia.

Sliptin 100 mg is typically prescribed for adults who require stronger glycemic control or those already tolerating lower doses (such as 50 mg) but still need improved blood glucose management. It can be used as monotherapy or in combination with other antidiabetic agents, including metformin, sulfonylureas, or insulin, to achieve optimal glycemic control.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

• Sitagliptin 100 mg per tablet

Mechanism of Action

Sliptin Tablet 100 mg selectively inhibits the Dipeptidyl Peptidase-4 (DPP-4) enzyme, which is responsible for the degradation of incretin hormones:

• GLP-1 (Glucagon-Like Peptide-1) and GIP (Glucose-dependent Insulinotropic Polypeptide) stimulate postprandial insulin secretion

• DPP-4 inhibition prolongs incretin activity, resulting in:

  • Increased insulin secretion from pancreatic beta cells in response to elevated glucose

  • Reduced glucagon secretion from pancreatic alpha cells, decreasing hepatic glucose production

• Since action is glucose-dependent, insulin is released primarily when blood glucose is elevated, lowering the risk of hypoglycemia

• Improves both fasting and postprandial blood glucose levels

Indications

Sliptin Tablet 100 mg is indicated for:

• Type 2 diabetes mellitus in adults inadequately controlled with diet and exercise

• Combination therapy with metformin, sulfonylureas, or insulin for better glycemic control

• Patients seeking once-daily oral therapy with a low risk of hypoglycemia

• Long-term management of type 2 diabetes to prevent complications associated with chronic hyperglycemia

Dosage and Administration

• The recommended dose is 100 mg once daily, taken orally with or without food

• Swallow the tablet whole; do not crush or chew

• Take at the same time each day to maintain consistent blood sugar control

• Dose adjustments may be necessary in patients with renal impairment

• Can be used alone or in combination with other antidiabetic agents as prescribed by a physician

Benefits

• Effectively lowers fasting and postprandial blood glucose

• Glucose-dependent mechanism reduces the risk of hypoglycemia

• Convenient once-daily dosing improves patient adherence

• Can be safely combined with other antidiabetic agents for enhanced glycemic control

• Supports long-term metabolic health and reduces risk of diabetes-related complications

Precautions

• Not indicated for type 1 diabetes or diabetic ketoacidosis

• Monitor renal and hepatic function, especially in patients with impairment

• Maintain diet and exercise alongside medication

• Use during pregnancy or lactation only if benefits outweigh risks; consult a healthcare provider 

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন  

Possible Side Effects

Common side effects:

• Headache

• Nasopharyngitis

• Mild gastrointestinal upset, such as nausea or diarrhea

Rare but serious side effects:

• Pancreatitis (persistent abdominal pain, possibly radiating to the back)

• Hypersensitivity reactions (rash, swelling, hives)

• Severe joint pain or heart failure exacerbation in predisposed patients

Storage

Store in a cool, dry place below 30°C, away from direct sunlight and moisture. Keep out of reach of children.

Sliptin Tablet 100 mg is an effective, safe, and convenient option for adults with type 2 diabetes, helping to improve insulin response, suppress glucagon, manage blood glucose, and support long-term metabolic health.