Sixtin Tablet 2.5 mg contains Saxagliptin, an oral antihyperglycemic agent used for the management of type 2 diabetes mellitus. Saxagliptin belongs to the class of Dipeptidyl Peptidase-4 (DPP-4) inhibitors, which help regulate blood glucose levels by enhancing the body’s natural incretin system. By inhibiting DPP-4, Sixtin prolongs the action of incretin hormones, leading to increased insulin release and decreased glucagon secretion in a glucose-dependent manner, helping patients maintain better glycemic control.

Sixtin Tablet 2.5 mg is typically prescribed for adults with type 2 diabetes who cannot achieve adequate glycemic control through diet and exercise alone. It may be used as monotherapy or in combination with other antidiabetic medications, including metformin, sulfonylureas, or insulin, to improve overall blood sugar management.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

• Saxagliptin 2.5 mg per tablet

Mechanism of Action

Sixtin Tablet 2.5 mg works by selectively inhibiting Dipeptidyl Peptidase-4 (DPP-4), an enzyme responsible for the degradation of incretin hormones:

• Incretin hormones (GLP-1 and GIP) increase insulin secretion in response to meals

• Inhibition of DPP-4 prolongs incretin activity

• Enhances insulin release from pancreatic beta cells only when glucose levels are elevated

• Suppresses glucagon secretion from pancreatic alpha cells, reducing hepatic glucose production

• Results in improved postprandial and fasting blood glucose levels

Because its action is glucose-dependent, Saxagliptin carries a low risk of hypoglycemia compared to some other antidiabetic agents.

Indications

Sixtin Tablet 2.5 mg is indicated for:

• Management of type 2 diabetes mellitus in adults

• Patients inadequately controlled with diet and exercise alone

• Combination therapy with metformin, sulfonylureas, or insulin for better glycemic control

• Patients seeking an oral antidiabetic with low hypoglycemia risk

Dosage and Administration

• The recommended dose is 2.5 mg once daily, taken orally, with or without food.

• In combination therapy, follow physician instructions carefully to prevent hypoglycemia.

• Consistent daily intake is important for optimal glucose management.

• Dose adjustments may be necessary in patients with renal impairment; consult a healthcare provider.

Benefits

• Improves fasting and postprandial blood glucose levels

• Enhances pancreatic insulin secretion in a glucose-dependent manner

• Reduces glucagon secretion and hepatic glucose output

• Convenient once-daily oral dosing

• Low risk of hypoglycemia compared to sulfonylureas or insulin

• Well-tolerated and suitable for long-term management of type 2 diabetes

Precautions

• Use cautiously in patients with renal or hepatic impairment; dose adjustment may be required

• Not indicated for type 1 diabetes or diabetic ketoacidosis

• Regular blood glucose monitoring is recommended

• Patients should maintain diet and exercise routines alongside medication

• Consult a physician before use during pregnancy or lactation

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Possible Side Effects

Common side effects include:

• Nasopharyngitis

• Headache or dizziness

• Nausea or mild gastrointestinal upset

Rare but serious side effects:

• Hypersensitivity reactions (rash, hives, or swelling)

• Pancreatitis (persistent abdominal pain with or without vomiting)

• Severe joint pain or heart failure exacerbation in predisposed patients

Storage

Store in a cool, dry place below 30°C, away from direct sunlight and moisture. Keep out of reach of children.

Sixtin Tablet 2.5 mg provides an effective, convenient, and safe option for managing type 2 diabetes, improving glycemic control while minimizing the risk of hypoglycemia, and supporting long-term metabolic health.