Seropam Tablet 10 mg contains Escitalopram Oxalate, a selective serotonin reuptake inhibitor (SSRI) used in the treatment of depression and anxiety disorders. By increasing serotonin levels in the brain, Seropam helps improve mood, reduce anxiety, and enhance overall emotional well-being. It is widely prescribed for patients suffering from major depressive disorder (MDD), generalized anxiety disorder (GAD), panic disorder, and social anxiety disorder, providing a balanced approach to mental health management.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Indications

Seropam 10 mg is indicated for:

• Major depressive disorder (MDD) – alleviates symptoms such as low mood, loss of interest, fatigue, and sleep disturbances

• Generalized anxiety disorder (GAD) – reduces excessive worry, tension, and restlessness

• Panic disorder – decreases the frequency and severity of panic attacks

• Social anxiety disorder – helps manage fear of social situations and performance anxiety

Pharmacology and Mode of Action

Escitalopram Oxalate, the active ingredient, is a selective serotonin reuptake inhibitor (SSRI) that works by:

1. Inhibiting the reuptake of serotonin (5-HT) at presynaptic nerve terminals

2. Increasing serotonin levels in the synaptic cleft

3. Enhancing neurotransmission in serotonin-dependent pathways, which improves mood and reduces anxiety

This selective mechanism minimizes effects on other neurotransmitters, resulting in fewer side effects compared to older antidepressants.

Dosage and Administration

• Adults: 10 mg orally once daily, with or without food

• Depending on clinical response, the dose may be increased up to 20 mg once daily after at least one week of treatment

• Elderly patients: Start with 5 mg daily and adjust gradually

• Administration: Take at the same time each day to maintain steady drug levels

• Duration: Continued treatment is often required for 6–12 months or longer, depending on patient response

Drug Interactions

• MAO inhibitors: Concomitant use can lead to serotonin syndrome; avoid combination

• Other serotonergic drugs: Increased risk of serotonin syndrome when combined with triptans, SNRIs, or St. John’s Wort

• CYP3A4/CYP2C19 inhibitors (e.g., omeprazole, fluconazole) may increase escitalopram levels

• Warfarin: Escitalopram may increase INR; monitor anticoagulation

• NSAIDs or aspirin: Increased risk of bleeding

Contraindications

Seropam is contraindicated in patients with:

• Hypersensitivity to Escitalopram or citalopram

• Concomitant use of MAO inhibitors or within 14 days of stopping MAO inhibitors

• History of serotonin syndrome

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Side Effects

Seropam is generally well tolerated. Common side effects include:

• Nausea, diarrhea, constipation

• Headache, dizziness, or fatigue

• Insomnia or somnolence

• Sexual dysfunction (decreased libido, delayed ejaculation)

• Rare: QT prolongation, serotonin syndrome, hyponatremia

Precautions and Warnings

• Monitor for suicidal thoughts, especially in adolescents and young adults

• Gradual dose reduction is recommended when discontinuing to avoid withdrawal symptoms

• Caution in patients with liver or kidney impairment

• May cause hyponatremia or electrolyte imbalance, particularly in elderly patients

Pregnancy and Lactation

• Use only if the potential benefit outweighs the risk; safety during pregnancy is not fully established

• Escitalopram is excreted in breast milk; monitor infants if the mother is treated during lactation

Storage Conditions

• Store below 30°C, protected from light and moisture

• Keep out of reach of children

• Do not use after the expiry date.