Amdocal Pro Tablet 2.5 mg + 5 mg is a combination antihypertensive therapy containing Bisoprolol Fumarate (2.5 mg) and Amlodipine Besilate (5 mg). It is designed for patients who require dual therapy to control high blood pressure or manage coronary artery disease. By combining a beta-blocker (Bisoprolol) with a calcium channel blocker (Amlodipine), Amdocal Pro provides complementary mechanisms to reduce blood pressure, improve cardiac function, and relieve angina symptoms, all in a convenient single tablet.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Indications

Amdocal Pro Tablet is indicated for:

• Hypertension (high blood pressure) requiring combination therapy

• Coronary artery disease (CAD), including:

  • Chronic stable angina

  • Vasospastic (Prinzmetal’s) angina

• Patients inadequately controlled with monotherapy of either Bisoprolol or Amlodipine

Therapeutic Class

Combination antihypertensive therapy: Beta-blocker + Calcium-channel blocker

Pharmacology

Bisoprolol Fumarate:
Bisoprolol is a selective beta-1 adrenergic receptor blocker. It reduces heart rate, cardiac output, and myocardial oxygen demand, thereby lowering blood pressure and relieving angina. It also decreases renin release from the kidneys, contributing to long-term blood pressure control.

Amlodipine Besilate:
Amlodipine is a long-acting calcium channel blocker that inhibits calcium influx into vascular smooth muscle and cardiac muscle. This action causes peripheral vasodilation, reduces peripheral resistance, and lowers blood pressure. In coronary arteries, amlodipine improves myocardial oxygen delivery and reduces ischemic episodes.

Combined Effect:
The combination of bisoprolol and amlodipine produces additive antihypertensive effects: Bisoprolol reduces heart rate and cardiac workload, while amlodipine decreases vascular resistance. Together, they improve blood pressure control and reduce angina without significant reflex tachycardia.

Dosage and Administration

Adults:

• One tablet daily, preferably at the same time each day

• Dose adjustments should be made based on blood pressure, heart rate, and tolerability

Special Populations:

• Elderly or fragile patients: Start at the lowest effective dose and titrate carefully

• Hepatic impairment: Use with caution; titrate slowly

• Renal impairment: No dose adjustment usually required, but monitor renal function

Administration should follow the guidance of a healthcare professional.

Drug Interactions

Amdocal Pro may interact with:

• Other antihypertensives, including ACE inhibitors, diuretics, or alpha-blockers

• Antiarrhythmic agents

• Non-dihydropyridine calcium channel blockers (e.g., verapamil, diltiazem)

• CYP3A4 inhibitors or inducers

• Digoxin or other drugs affecting heart rate

Concomitant use may require careful monitoring or dose adjustments.

Contraindications

• Known hypersensitivity to bisoprolol, amlodipine, or any component of the formulation

• Severe bradycardia, heart block, or cardiogenic shock

• Decompensated heart failure or severe hypotension

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Side Effects

Common:

• Headache

• Fatigue

• Dizziness

• Peripheral edema (ankle swelling)

• Bradycardia

Less common:

• Palpitations

• Nausea, flushing

• Gastrointestinal discomfort

Precautions and Warnings

• Monitor blood pressure and heart rate regularly

• Use cautiously in patients with hepatic impairment, asthma, or diabetes

• Avoid abrupt discontinuation, especially of bisoprolol, to prevent rebound angina or hypertension

• Pregnancy Category C: Use only if benefits outweigh risks

Overdose

Symptoms may include excessive hypotension, bradycardia, or heart block. Management includes:

• Supportive cardiovascular care

• Intravenous fluids, atropine for bradycardia

• Vasopressors for hypotension

• Activated charcoal if recently ingested

Storage Conditions

Store in a dry, cool place away from light and heat.
Keep out of reach of children.

Mode of Action

• Bisoprolol: Selective beta-1 blockade reduces heart rate, cardiac output, and myocardial oxygen demand.

• Amlodipine: Calcium channel blockade causes vasodilation, reducing peripheral resistance and improving coronary blood flow.

Together, they provide effective blood pressure control and angina relief.