Serelose Oral Solution 3.35 gm/5 ml is a synthetic disaccharide laxative containing Lactulose, used to treat constipation and hepatic encephalopathy. Lactulose is a non-digestible sugar that exerts its effects in the colon, promoting bowel movements and reducing blood ammonia levels in patients with liver disease. Serelose is particularly effective for chronic constipation, impaction, and as part of therapy to prevent hepatic encephalopathy in patients with liver cirrhosis or portal-systemic shunts.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Indications

Serelose Oral Solution is indicated for:

• Chronic constipation in adults and children

• Acute constipation when rapid relief is needed

• Hepatic encephalopathy to reduce ammonia absorption in patients with liver disease

• Bowel preparation before certain diagnostic procedures

By increasing bowel water content and improving peristalsis, Serelose provides gentle, predictable relief without causing harsh cramping.

Pharmacology and Mode of Action

Lactulose is a synthetic, non-absorbable disaccharide composed of galactose and fructose. Its mechanisms include:

1. Osmotic effect: Lactulose is metabolized by colonic bacteria to organic acids, increasing osmotic pressure and drawing water into the colon

2. Acidification of colonic contents: Reduces intestinal pH, converting ammonia (NH₃) to ammonium (NH₄⁺), which is less absorbable, helping lower systemic ammonia levels

3. Promotion of bowel motility: Softens stools and stimulates peristalsis for regular bowel movements

This dual effect makes Serelose suitable for both constipation relief and management of hepatic encephalopathy.

Dosage and Administration

• For constipation:

  • Adults: 15–45 ml per day, divided into 1–3 doses

  • Children: 5–15 ml per day, depending on age

  • Adjust dose to achieve 1–2 soft stools daily

• For hepatic encephalopathy:

  • Initial dose: 30–45 ml orally, 3–4 times daily

  • Dose may be titrated to achieve 2–3 soft bowel movements per day

• Can be taken with or without food

• May be diluted in water, milk, or juice for easier administration

• Maintain adequate hydration during treatment

Drug Interactions

• Minimal systemic absorption reduces the likelihood of significant drug interactions

• Concurrent use with other osmotic or stimulant laxatives may enhance the laxative effect

• Electrolyte imbalance may occur in combination with diuretics during long-term therapy

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Contraindications

Serelose Oral Solution should not be used in patients with:

• Known hypersensitivity to Lactulose

• Galactosemia (inborn intolerance to galactose)

• Intestinal obstruction or undiagnosed abdominal pain

Side Effects

Serelose is generally well tolerated. Common side effects include:

• Flatulence and bloating

• Abdominal discomfort or cramping

• Diarrhea if the dose is too high

• Rare: Electrolyte imbalance with prolonged use in the elderly or debilitated patients

Precautions and Warnings

• Monitor patients with diabetes, as Lactulose contains sugars that may slightly affect blood glucose

• Use cautiously in patients with severe dehydration or electrolyte disorders

• Adjust dose in elderly or frail patients to avoid excessive laxation

Pregnancy and Lactation

• Lactulose is considered safe in pregnancy and breastfeeding due to minimal systemic absorption

• Use only as directed to avoid excessive diarrhea

Storage Conditions

• Store in a cool, dry place below 30°C, protected from light

• Keep out of reach of children

• Do not use after the expiry date.