Combocef Tablet 100 mg + 62.5 mg is a combination antibiotic containing Cefpodoxime Proxetil, a third-generation cephalosporin, and Clavulanic Acid, a beta-lactamase inhibitor. This formulation is designed to effectively treat a wide range of bacterial infections by enhancing the activity of Cefpodoxime against resistant bacteria. The lower-strength dosage is particularly suitable for mild to moderate infections or for patients requiring adjusted dosing.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Indications

Combocef Tablet is indicated for the treatment of:

• Upper respiratory tract infections such as sinusitis, pharyngitis, and tonsillitis
• Lower respiratory tract infections including bronchitis
• Urinary tract infections (UTIs)
• Skin and soft tissue infections
• Ear infections (otitis media)
• Other bacterial infections caused by susceptible organisms

Mechanism of Action

• Cefpodoxime Proxetil: Inhibits bacterial cell wall synthesis, leading to bacterial death.
• Clavulanic Acid: Inhibits beta-lactamase enzymes that would otherwise degrade Cefpodoxime, thereby extending its antibacterial spectrum.

This combination provides a synergistic effect, improving treatment outcomes in resistant infections.

Dosage and Administration

• The usual dose is one tablet twice daily, or as directed by a physician
• Take with food to enhance absorption
• Swallow the tablet whole with water; do not crush or chew
• Complete the full course of treatment even if symptoms improve early

Benefits

• Broad-spectrum antibacterial coverage
• Effective against beta-lactamase producing resistant bacteria
• Suitable for mild to moderate infections
• Lower-dose option for flexible dosing and improved tolerance
• Convenient oral tablet form

Side Effects

Common side effects may include:

• Nausea
• Diarrhea
• Abdominal discomfort
• Headache

Rare but serious side effects:

• Allergic reactions (rash, itching, swelling)
• Severe diarrhea or antibiotic-associated colitis
• Liver function abnormalities

Seek immediate medical attention if serious side effects occur.

Precautions

• Use cautiously in patients with a history of allergy to penicillins or cephalosporins
• Dose adjustment may be required in renal impairment
• Prolonged use may lead to secondary infections
• Inform your doctor about all other medications being taken

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Use in Special Populations

• Pregnancy: Use only if clearly necessary and under medical supervision
• Lactation: Generally considered safe; consult a healthcare provider
• Children: Dose adjustment based on body weight is required

Storage

• Store below 30°C
• Keep in a dry place, protected from light
• Keep out of reach of children.