Resitone Tablet 20 mg + 50 mg is a combination diuretic formulation containing Furosemide 20 mg and Spironolactone 50 mg, designed to manage fluid retention associated with various cardiovascular and renal conditions. By combining a loop diuretic (furosemide) with a potassium-sparing diuretic (spironolactone), Resitone provides potent diuretic effects while minimizing potassium loss, offering a balanced approach to fluid and electrolyte management.

This dual-action therapy is particularly useful in patients with edema related to congestive heart failure, liver cirrhosis, nephrotic syndrome, or other conditions causing fluid overload. Resitone helps reduce swelling, lower blood pressure, and prevent complications associated with excessive fluid accumulation.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Therapeutic Class

Diuretic Combination (Loop + Potassium-Sparing)

Composition

Each tablet contains:

• Furosemide 20 mg – Loop diuretic

• Spironolactone 50 mg – Potassium-sparing diuretic

Indications

Resitone Tablet is indicated for:

• Edema Management: Associated with congestive heart failure, liver cirrhosis, or nephrotic syndrome

• Hypertension: Especially in patients requiring diuretic therapy

• Prevention of Hypokalemia: When diuretic therapy is likely to cause potassium depletion

Pharmacology

Furosemide acts on the ascending loop of Henle in the kidney, inhibiting sodium, chloride, and water reabsorption, which leads to a potent diuretic effect. It is effective in mobilizing edema and reducing fluid overload rapidly.

Spironolactone is an aldosterone antagonist that acts on the distal renal tubules, inhibiting sodium reabsorption and potassium excretion. This potassium-sparing effect counteracts the potassium loss associated with furosemide, reducing the risk of hypokalemia.

Together, the combination achieves effective diuresis with better electrolyte balance, making it suitable for long-term management of edema and hypertension.

Mode of Action

• Furosemide: Promotes excretion of sodium, chloride, and water by inhibiting the loop of Henle

• Spironolactone: Blocks aldosterone receptors, preventing potassium loss and sodium retention

• Combination Effect: Reduces edema and blood pressure while maintaining potassium homeostasis

Dosage and Administration

• The dosage of Resitone Tablet must be individualized based on the severity of edema, renal function, and patient response.

• Usual Starting Dose: One tablet once daily or as directed by the physician

• Adjustments: Dose can be increased gradually according to clinical response.

• Should be taken with food to reduce gastrointestinal irritation.

• Monitoring: Regular monitoring of electrolytes, kidney function, and blood pressure is recommended during therapy.

Drug Interactions

• ACE inhibitors, ARBs, or potassium supplements: May increase the risk of hyperkalemia due to spironolactone

• NSAIDs: May reduce diuretic efficacy and increase the risk of renal impairment

• Other antihypertensives: May potentiate hypotensive effects

• Lithium: Risk of lithium toxicity may increase with diuretics

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Contraindications

• Known hypersensitivity to furosemide, spironolactone, or any excipients

• Hyperkalemia or severe renal impairment

• Anuria

• Addison’s disease

• Pregnancy and breastfeeding (use only if clearly necessary and under medical supervision)

Side Effects

Common adverse effects may include:

• Dizziness or lightheadedness

• Headache

• Gastrointestinal disturbances (nausea, vomiting)

• Electrolyte imbalances (hyperkalemia, hyponatremia)

• Fatigue or muscle cramps

Rare side effects: rash, gynecomastia (from spironolactone), hypotension, or kidney dysfunction

Precautions and Warnings

• Monitor serum electrolytes and renal function regularly

• Use caution in patients with liver dysfunction or heart failure

• Avoid abrupt discontinuation in long-term therapy

• Patients should be advised to report symptoms such as muscle weakness, palpitations, or severe dizziness

Storage Conditions

Store in a cool, dry place below 30°C.
Keep out of reach of children.