Yonex Injection 1 MIU (34 mg) contains Colistimethate Sodium, a potent polymyxin antibiotic used for the treatment of serious infections caused by multidrug-resistant Gram-negative bacteria. It is reserved for severe hospital-acquired infections where other antibiotics are ineffective or unsuitable. This medicine is commonly used in intensive care settings under strict medical supervision.

Colistimethate Sodium is a prodrug that is converted in the body into colistin, its active form. Colistin acts by disrupting the bacterial cell membrane, leading to leakage of essential intracellular components and rapid bacterial cell death. Because of its strong activity against resistant organisms, it is an important option in critical infections caused by bacteria such as Pseudomonas aeruginosa, Klebsiella pneumoniae, and Acinetobacter species.

Yonex Injection 1 MIU is used in lower-dose regimens, dose adjustments, or pediatric and renal-impaired patients where careful titration is required. Treatment must always be individualized and closely monitored to reduce the risk of toxicity.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

Each vial contains:

• Colistimethate Sodium USP 1 MIU (equivalent to 34 mg)

Indications

Yonex Injection is indicated for:

• Severe multidrug-resistant Gram-negative bacterial infections
• Hospital-acquired pneumonia (HAP)
• Ventilator-associated pneumonia (VAP)
• Bloodstream infections (sepsis)
• Urinary tract infections caused by resistant organisms
• Intra-abdominal infections
• Other serious systemic infections when alternatives are not effective

How It Works

Colistimethate Sodium is converted into colistin in the body. Colistin binds to the lipopolysaccharides and phospholipids in the bacterial cell membrane, disrupting membrane integrity and causing bacterial cell death.

Dosage and Administration

Yonex Injection must be administered by a qualified healthcare professional.

• Administered by intravenous infusion or intramuscular injection
• Dose depends on severity of infection, body weight, and renal function
• Requires careful dose adjustment in kidney impairment
• Continuous monitoring of renal function is essential during therapy

Benefits of Yonex Injection

• Effective against multidrug-resistant Gram-negative bacteria
• Useful in life-threatening hospital infections
• Important option when other antibiotics fail
• Provides rapid bactericidal action
• Suitable for ICU and critical care use

Precautions

Use cautiously in:

• Patients with kidney impairment (high risk of nephrotoxicity)
• Neuromuscular disorders
• Elderly patients
• Patients receiving other nephrotoxic drugs
• Pregnancy and breastfeeding only if clearly necessary

Regular monitoring of kidney function and neurological status is required during treatment.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Possible Side Effects

Common side effects may include:

• Kidney toxicity (increased creatinine levels)
• Nausea and vomiting
• Dizziness
• Tingling or numbness
• Muscle weakness
• Injection site reactions

Serious adverse effects require immediate medical attention.

Storage

• Store below 25–30°C
• Protect from light and moisture
• Keep out of reach of children.