Coughex Tablet 45 mg contains Gefapixant Citrate, a selective P2X3 receptor antagonist used for the treatment of refractory or unexplained chronic cough. It works by reducing the hypersensitivity of airway sensory nerves, thereby decreasing the cough reflex. Coughex is designed for patients whose cough persists despite standard treatment.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

• Active Ingredient: Gefapixant Citrate 45 mg
• Dosage Form: Oral tablet

Mechanism of Action

Gefapixant selectively blocks P2X3 receptors located on sensory nerve fibers in the respiratory tract. These receptors are activated by ATP released during airway irritation. By inhibiting this signaling pathway, Coughex reduces nerve hypersensitivity and suppresses chronic cough without affecting normal protective cough reflexes significantly.

Indications

Coughex Tablet 45 mg is indicated for:

• Refractory chronic cough
• Unexplained chronic cough
• Chronic cough not responding to standard antitussive therapy
• Persistent cough associated with airway hypersensitivity

Dosage and Administration

• Must be taken as directed by a healthcare professional
• Commonly administered twice daily (as prescribed)
• Can be taken with or without food
• Swallow tablet whole with water
• Regular follow-up is recommended to assess response

Precautions

• Use with caution in patients with renal impairment
• Not recommended during pregnancy unless clearly necessary
• May cause taste disturbances in some patients
• Inform physician about all ongoing medications
• Long-term use should be monitored by a specialist

Side Effects

Common side effects include:

• Altered taste sensation (dysgeusia)
• Nausea
• Diarrhea
• Dizziness

Serious but rare effects:

• Severe hypersensitivity reactions
• Persistent gastrointestinal discomfort

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Storage

• Store below 30°C in a dry place
• Protect from moisture and light
• Keep out of reach of children

Conclusion

Coughex Tablet 45 mg (Gefapixant Citrate) is a novel antitussive therapy designed for chronic refractory cough. It works by targeting airway nerve hypersensitivity, offering relief for patients who do not respond to conventional cough treatments under medical supervision.