Probis Plus Tablet 5 mg+6.25 mg is a potent combination medication designed to manage high blood pressure (hypertension) and reduce cardiovascular risk. It contains Bisoprolol Fumarate 5 mg, a beta-1 selective blocker, and Hydrochlorothiazide 6.25 mg, a thiazide diuretic. By targeting two complementary pathways, Probis Plus helps lower blood pressure effectively, protect the heart, and prevent complications associated with hypertension.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Mechanism of Action

• Bisoprolol Fumarate: Selectively blocks beta-1 adrenergic receptors in the heart, slowing the heart rate and reducing cardiac contractility. This decreases cardiac workload and lowers blood pressure.
• Hydrochlorothiazide: A thiazide diuretic that promotes excretion of sodium and water via the kidneys, reducing blood volume and further lowering blood pressure.

The combination ensures dual-action antihypertensive control, providing greater effectiveness than monotherapy while minimizing side effects by allowing moderate doses of each drug.

Indications

Probis Plus Tablet 5 mg+6.25 mg is primarily indicated for:

• Management of primary hypertension
• Patients requiring enhanced blood pressure control after initial therapy
• Reducing cardiovascular risk in patients with heart disease or other comorbidities

Dosage and Administration

• Typically taken as one tablet once daily, or as directed by a physician.
• Can be taken with or without food, preferably at the same time each day.
• Regular monitoring of blood pressure, kidney function, and electrolytes is recommended during therapy.

Benefits

• Offers effective dual blood pressure control through beta-blockade and diuretic action
• May reduce the risk of heart attack, stroke, and heart failure
• Convenient once-daily dosing improves patient adherence
• Suitable for patients who require higher-dose beta-blocker therapy alongside diuretic support

Precautions

• Not recommended for patients with severe bradycardia, hypotension, or advanced kidney disease.
• Use with caution in patients with diabetes, gout, or electrolyte disturbances.
• Inform your doctor about all other medications to avoid interactions.
• Abrupt discontinuation can worsen heart conditions; gradual tapering under medical supervision is advised.

Side Effects

Common side effects may include:

• Dizziness or lightheadedness
• Fatigue
• Headache
• Swelling of the ankles or feet
• Increased urination

Serious adverse reactions are rare but require immediate attention, including extremely low blood pressure, slow heart rate, or severe allergic responses.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Storage

• Store in a cool, dry place, protected from sunlight and moisture.
• Keep out of reach of children.

Probis Plus Tablet 5 mg+6.25 mg provides reliable, effective blood pressure management for patients needing a higher dose of beta-blocker therapy combined with diuretic support, ensuring long-term cardiovascular protection.