Inclox 500 mg contains Flucloxacillin, a penicillinase-resistant penicillin antibiotic used for the treatment of infections caused by Gram-positive bacteria, particularly penicillinase-producing staphylococci. It is a bactericidal antibiotic widely prescribed for skin, respiratory, bone, and systemic infections where resistant staphylococcal strains are suspected or confirmed. Inclox 500 mg is also used prophylactically during certain major surgical procedures to prevent postoperative infections.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Therapeutic Class

Penicillinase-resistant penicillins

Pharmacology

Flucloxacillin is an isoxazolyl penicillin that inhibits bacterial cell wall synthesis, leading to bacterial cell death. It acts by binding to penicillin-binding proteins (PBPs) and blocking the transpeptidase enzyme involved in the final stage of peptidoglycan synthesis. This prevents cross-linking of the bacterial cell wall, resulting in weakening, swelling, and eventual rupture of the bacterial cell.
Flucloxacillin is highly resistant to hydrolysis by staphylococcal penicillinase due to steric hindrance from its acyl side chain. It is stable in acidic conditions and is particularly effective against Gram-positive organisms, while its activity against Gram-negative bacilli is limited.

Indications

Inclox 500 mg is indicated for the treatment of infections caused by susceptible Gram-positive organisms, including penicillinase-producing staphylococci, such as:

Skin and Soft Tissue Infections

• Boils, abscesses, carbuncles

• Infected ulcers, eczema, acne, furunculosis

• Cellulitis, infected wounds, and burns

Respiratory Tract Infections

• Pneumonia

• Lung abscess

• Empyema

• Sinusitis, pharyngitis, tonsillitis, quinsy

Other Infections

• Osteomyelitis

• Enteritis

• Endocarditis

• Urinary tract infections

• Meningitis

• Septicaemia

Prophylactic Use

• Prevention of infections during major surgical procedures, especially cardiothoracic and orthopedic surgeries, when clinically indicated

Dosage and Administration

Oral Administration

• Adults: 250 mg four times daily; dose may be doubled in severe infections

• Osteomyelitis and endocarditis: Up to 8 g daily in divided doses every 6–8 hours

• Children (2–10 years): Half of the adult dose

• Children (under 2 years): One quarter of the adult dose

Parenteral Administration

• Adults/Elderly:

  • Intramuscular: 250 mg four times daily

  • Intravenous: 250 mg to 1 g four times daily by slow IV injection or infusion

  • Severe infections: Doses may be doubled; up to 8 g daily for endocarditis or osteomyelitis

• Children:

  • 2–10 years: Half of the adult dose

  • Under 2 years: One quarter of the adult dose

Administration Note:
Oral doses should be taken 1 hour before meals for optimal absorption.

Drug Interactions

In patients with severe renal failure (creatinine clearance <10 ml/min), dose reduction or prolongation of dosing interval should be considered.

Contraindications

Inclox 500 mg is contraindicated in patients with known hypersensitivity to penicillins.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Side Effects

Common adverse effects include nausea, vomiting, diarrhea, dyspepsia, and other mild gastrointestinal disturbances. Hypersensitivity reactions such as rash, urticaria, fever, purpura, interstitial nephritis, hepatitis, and cholestatic jaundice have been reported.

Precautions and Warnings

Caution is advised in patients with existing liver dysfunction or a history of allergic reactions. Liver function should be monitored during prolonged therapy.

Use in Special Populations

• Renal impairment: Dose reduction or extended dosing interval is recommended in severe renal failure

• Pediatric patients: Dosage adjustment is required based on age and renal function

Pregnancy and Lactation

Inclox 500 mg is classified as US FDA Pregnancy Category B. There are no adequate, well-controlled studies in pregnant women; therefore, it should be used during pregnancy only if clearly necessary. Flucloxacillin is excreted in breast milk, and caution should be exercised when administered to lactating mothers.

Storage Conditions

Store in a dry place away from light and heat. Keep out of reach of children.