Patron Tablet 0.5 mg contains Palonosetron, a selective 5-HT3 receptor antagonist that is used to prevent nausea and vomiting associated with chemotherapy and surgical procedures. Palonosetron works by blocking serotonin receptors (5-HT3) in the gastrointestinal tract and the central nervous system, which are primarily responsible for triggering the vomiting reflex.

The tablet form provides a convenient oral alternative to injections, making it suitable for patients who prefer non-invasive administration. Patron Tablet is particularly effective for patients undergoing moderately or highly emetogenic chemotherapy, as well as those at risk of postoperative nausea and vomiting (PONV), ensuring better comfort and compliance with treatment regimens.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Key Benefits

• Prevents chemotherapy-induced nausea and vomiting (CINV)

• Effective in both acute (0–24 hours) and delayed (24–120 hours) phases of CINV

• Reduces postoperative nausea and vomiting (PONV)

• Oral tablet form provides a convenient and non-invasive option

• Long-acting with extended antiemetic protection

• Improves patient comfort, quality of life, and treatment adherence

Mechanism of Action

Palonosetron, the active ingredient in Patron Tablet, acts as a highly selective 5-HT3 receptor antagonist:

1. Serotonin Receptor Blockade:

   • Chemotherapy or surgical procedures can cause serotonin release from enterochromaffin cells in the gastrointestinal tract.

   • Serotonin binds to 5-HT3 receptors on vagal nerve endings, triggering the vomiting center in the brain.

   • Palonosetron blocks these receptors, preventing nausea and vomiting signals from reaching the brain.

2. Peripheral and Central Action:

   • Works on 5-HT3 receptors in the gut and central nervous system, offering comprehensive antiemetic protection.

3. Long Half-Life:

   • Palonosetron has a prolonged half-life, allowing a single oral dose to control both acute and delayed nausea effectively.

Indications

Patron Tablet 0.5 mg is indicated for:

• Prevention of chemotherapy-induced nausea and vomiting (CINV) in patients receiving moderately or highly emetogenic chemotherapy

• Prevention of postoperative nausea and vomiting (PONV) in adults undergoing surgery

• Part of multimodal antiemetic therapy to improve patient comfort and treatment adherence

Dosage and Administration

• Adults: One 0.5 mg tablet taken orally approximately 1 hour before chemotherapy or surgery.

• Pediatrics: Use under strict medical supervision, with dosing adjusted according to body weight and clinical judgment.

• The tablet can be taken with or without food, but swallowing with water is recommended.

• No routine dose adjustment is required in mild to moderate renal or hepatic impairment, but consult a physician for severe cases.

Precautions and Warnings

• Use caution in patients with cardiac arrhythmias or prolonged QT interval.

• Pregnancy and breastfeeding women should take Patron Tablet only if clearly indicated and under medical supervision.

• Rare side effects may include headache, constipation, fatigue, or transient changes in liver enzymes.

• Avoid combining with other drugs that significantly prolong the QT interval unless under supervision.

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Possible Side Effects

Patron Tablet is generally well-tolerated. Common side effects include:

• Headache

• Constipation

• Fatigue or dizziness

Severe side effects are rare but may include allergic reactions, arrhythmias, or severe hypersensitivity, requiring immediate medical attention.

Storage

Store below 30°C in a dry, cool place, protected from light. Keep out of reach of children.

Patron Tablet 0.5 mg provides effective, long-lasting prevention of chemotherapy- and surgery-induced nausea and vomiting, offering a convenient oral option to improve patient comfort and adherence to treatment protocols.