Informet XR Tablet 750 mg contains Metformin Hydrochloride in an extended-release (XR) formulation. It is an oral antidiabetic medication widely prescribed for the management of type 2 diabetes mellitus. The extended-release technology allows metformin to be released slowly over an extended period, ensuring consistent blood glucose control with improved gastrointestinal tolerability and convenient once-daily dosing.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Therapeutic Class

Biguanides
Oral Antidiabetic Agent

Composition

Each extended-release tablet contains Metformin Hydrochloride 750 mg.

Indications

Informet XR Tablet 750 mg is indicated for:

• Treatment of type 2 diabetes mellitus in adults

• Use as monotherapy when diet and exercise alone are inadequate

• Combination therapy with other oral antidiabetic agents or insulin to improve glycemic control

It is especially beneficial for patients who experience gastrointestinal side effects with immediate-release metformin or prefer a once-daily dosing regimen.

Pharmacology

Metformin is a biguanide that reduces blood glucose levels primarily by improving insulin sensitivity rather than increasing insulin secretion. Its mechanisms of action include:

• Suppression of hepatic glucose production

• Reduction of intestinal glucose absorption

• Enhancement of peripheral glucose uptake and utilization

The extended-release formulation of Informet XR ensures gradual absorption of metformin, leading to more stable plasma concentrations and reduced peak-related side effects. This helps maintain effective glycemic control throughout the day and night without significant risk of hypoglycemia when used alone.

Dosage and Administration

Dosage should be individualized based on the patient’s glycemic response and tolerance.

• Usually administered once daily with the evening meal

• Tablets must be swallowed whole and should not be crushed, split, or chewed

Dose titration should be gradual to minimize gastrointestinal discomfort. Treatment should always follow the guidance of a qualified healthcare professional.

Contraindications

Informet XR Tablet 750 mg is contraindicated in patients with:

• Severe renal impairment

• Acute or chronic metabolic acidosis, including diabetic ketoacidosis

• Known hypersensitivity to metformin hydrochloride

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Precautions and Warnings

• Renal function assessment is recommended before initiating therapy and periodically thereafter

• Use with caution in elderly patients due to possible reduced renal function

• Temporary discontinuation may be required during major surgical procedures or diagnostic imaging involving iodinated contrast agents

• Although rare, the risk of lactic acidosis should be considered, particularly in patients with renal, hepatic, or cardiovascular compromise

Adverse Effects

Common adverse effects include:

• Nausea

• Diarrhea

• Abdominal pain

• Decreased appetite

These effects are generally mild and transient and occur less frequently with extended-release formulations. Long-term therapy may lead to vitamin B12 deficiency in some patients.

Drug Interactions

Caution is advised when used concomitantly with:

• Alcohol

• Iodinated contrast media

• Diuretics and certain antihypertensive agents

When combined with other antidiabetic drugs, monitoring for hypoglycemia is recommended.

Storage

Store in a cool and dry place, away from direct sunlight and moisture. Keep out of reach of children.

Conclusion

Informet XR Tablet 750 mg is a reliable extended-release formulation of metformin that provides sustained glycemic control with enhanced tolerability and simplified dosing. It is an essential option in the long-term management of type 2 diabetes mellitus, supporting effective blood glucose regulation and improved patient adherence.