Osmotic Injection 20% contains Mannitol, a sterile osmotic diuretic solution used in emergency and hospital settings. It works by increasing plasma osmolarity, drawing excess fluid from tissues into the bloodstream, and promoting diuresis through the kidneys. It is widely used to reduce intracranial pressure, intraocular pressure, and to support renal function in specific medical conditions.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

• Active Ingredient: Mannitol 20% w/v (Sterile IV solution)

Indications

Osmotic Injection 20% (Mannitol) is indicated for:

• Reduction of elevated intracranial pressure (cerebral edema)
• Reduction of intraocular pressure (glaucoma or during ocular surgery)
• Promotion of diuresis in acute renal failure (oliguric phase)
• Reduction of cerebral swelling due to head injury or stroke
• Adjunct therapy in acute kidney injury management

Mechanism of Action

Mannitol is an osmotic agent that is freely filtered by the kidneys but not reabsorbed. It increases plasma osmolarity, pulling water from intracellular and interstitial spaces into the vascular compartment. This reduces tissue swelling in the brain and eyes and increases urine output by osmotic diuresis.

Dosage and Administration

• Administered intravenously only under medical supervision.
• Dosage depends on clinical condition, body weight, and response to therapy.
• Must be infused using a sterile IV set with careful monitoring of urine output and vital signs.
• Solution should be checked for crystals before administration; warming may be required to dissolve crystals.

Benefits

• Rapid reduction of intracranial pressure
• Effective lowering of intraocular pressure
• Promotes urine output in renal impairment
• Helps manage cerebral edema and acute neurological conditions
• Acts quickly in emergency situations

Side Effects

Osmotic Injection 20% (Mannitol) may cause:

• Electrolyte imbalance (e.g., hyponatremia, hypernatremia)
• Dehydration or fluid overload
• Headache or dizziness
• Nausea or vomiting
• Hypotension or hypertension
• Rare renal function changes with improper use

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Precautions and Warnings

• Use only under strict medical supervision in hospital settings.
• Contraindicated in anuria due to renal failure (except test dose response).
• Monitor renal function, electrolytes, and fluid balance regularly.
• Use caution in patients with heart failure or pulmonary congestion.
• Inspect solution for crystallization before use; do not administer if crystals persist.

Storage

• Store below 30°C
• Protect from freezing
• Keep container tightly closed
• Use only if solution is clear and free from crystals after warming.