Duovas Tablet 5 mg + 40 mg is a fixed-dose combination antihypertensive medication containing Amlodipine Besilate 5 mg and Olmesartan Medoxomil 40 mg. This combination is designed for the effective management of hypertension (high blood pressure) in patients who require dual therapy for optimal blood pressure control.

Hypertension is a major risk factor for serious cardiovascular complications, including stroke, heart attack, heart failure, and kidney disease. Duovas combines two complementary mechanisms of action to provide better and more sustained blood pressure reduction compared to monotherapy.

Amlodipine is a calcium channel blocker (CCB) that relaxes blood vessels by inhibiting calcium entry into vascular smooth muscle cells, resulting in vasodilation and reduced peripheral resistance.
Olmesartan Medoxomil is an angiotensin II receptor blocker (ARB) that prevents angiotensin II from binding to its receptors, thereby reducing vasoconstriction and decreasing aldosterone secretion. This leads to further relaxation of blood vessels and improved blood pressure control.

Together, these agents provide synergistic blood pressure reduction while maintaining good tolerability.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Therapeutic Class

• Antihypertensive Agent

• Calcium Channel Blocker + Angiotensin II Receptor Blocker (ARB) Combination

Indications

Duovas Tablet is indicated for:

• Treatment of essential hypertension

• Patients not adequately controlled with single-agent therapy

• Reduction of risk of cardiovascular complications associated with high blood pressure

• Long-term management of blood pressure to prevent target organ damage

It is not intended for the initial treatment of hypertension unless recommended by a physician.

Mechanism of Action

Amlodipine Besilate:

• Blocks L-type calcium channels

• Causes relaxation of peripheral arteries

• Reduces systemic vascular resistance and lowers blood pressure

Olmesartan Medoxomil:

• Selectively blocks angiotensin II type 1 (AT1) receptors

• Prevents vasoconstriction and sodium retention

• Reduces blood pressure and protects target organs such as the heart and kidneys

The combination ensures effective 24-hour blood pressure control with reduced risk of reflex tachycardia.

Dosage and Administration

• Recommended dose: one tablet once daily, or as prescribed by a physician

• Can be taken with or without food

• Swallow the tablet whole with water

• Regular monitoring of blood pressure is advised

• Dosage adjustments may be required based on patient response and tolerability

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Possible Side Effects

Duovas Tablet is generally well tolerated. Common side effects may include:

• Dizziness or light-headedness

• Peripheral edema (ankle swelling)

• Headache

• Fatigue

Rare but serious adverse effects may include hypotension, hyperkalemia, or allergic reactions. Medical advice should be sought if severe symptoms occur.

Precautions and Warnings

• Use cautiously in patients with renal impairment, hepatic dysfunction, or heart failure

• Monitor serum potassium and renal function periodically

• Not recommended during pregnancy, especially in the second and third trimesters

• Avoid use in patients with known hypersensitivity to any component

• Do not discontinue abruptly without medical advice

Storage

• Store below 30°C in a cool, dry place

• Protect from light and moisture

• Keep out of reach of children.