Metform ER Tablet 1000 mg contains Metformin Hydrochloride in an extended-release (ER) formulation, specially designed for the long-term management of type 2 diabetes mellitus. This formulation allows the medication to be released gradually over time, ensuring consistent blood glucose control throughout the day while minimizing gastrointestinal discomfort commonly associated with immediate-release metformin.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

• Active Ingredient: Metformin Hydrochloride 1000 mg (Extended Release)

Mechanism of Action

Metformin primarily works by decreasing hepatic glucose production (gluconeogenesis), reducing intestinal absorption of glucose, and improving insulin sensitivity in muscle and fat tissues. The extended-release technology ensures a slow and steady release of the drug, helping maintain stable plasma glucose levels and improving overall glycemic control.

Indications

Metform ER Tablet 1000 mg is indicated for:

• Management of type 2 diabetes mellitus
• Improving glycemic control in adults
• Patients requiring higher doses of metformin for adequate blood sugar control
• Use as monotherapy or in combination with other oral antidiabetic agents or insulin
• Prevention of long-term diabetes-related complications

Dosage and Administration

• The dosage should be determined by a physician based on individual patient needs
• Usually taken once daily with the evening meal
• Tablets must be swallowed whole with water; do not crush, chew, or split
• Dose titration should be gradual to reduce gastrointestinal side effects

Benefits

• Provides sustained and effective blood glucose control
• Convenient once-daily dosing improves adherence
• Reduced gastrointestinal side effects compared to immediate-release formulations
• Does not promote weight gain and may support modest weight reduction
• Low risk of hypoglycemia when used alone

Side Effects

Common side effects include:

• Nausea
• Diarrhea
• Abdominal discomfort
• Loss of appetite

Rare but serious side effect:

• Lactic acidosis, a potentially life-threatening condition, especially in patients with renal impairment

Precautions

• Use cautiously in patients with kidney, liver, or cardiovascular disease
• Regular monitoring of renal function is essential
• Avoid excessive alcohol consumption as it increases the risk of lactic acidosis
• Temporarily discontinue before major surgery or radiologic studies involving contrast dye
• Not recommended in severe renal impairment

Contraindications

• Severe kidney disease
• Acute or chronic metabolic acidosis (including diabetic ketoacidosis)
• Hypersensitivity to Metformin Hydrochloride

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Drug Interactions

Metformin may interact with:

• Other antidiabetic medications (risk of hypoglycemia)
• Diuretics, corticosteroids, and beta-agonists (may alter blood glucose levels)
• Iodinated contrast media (may increase risk of kidney complications)

Storage

• Store below 30°C in a cool, dry place
• Protect from light and moisture
• Keep out of reach of children.