Jakloc Tablet 5 mg contains Tofacitinib, an oral Janus kinase (JAK) inhibitor used in the treatment of autoimmune and inflammatory conditions. It works by reducing abnormal immune system activity, thereby decreasing inflammation, pain, and tissue damage in affected patients.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

• Tofacitinib 5 mg

Mechanism of Action

Tofacitinib selectively inhibits Janus kinase (JAK) enzymes, which are involved in the signaling pathways of inflammatory cytokines. By blocking these pathways, it reduces immune-mediated inflammation and helps control symptoms of autoimmune diseases such as joint pain, swelling, and stiffness.

Indications

Jakloc Tablet is indicated for:

• Rheumatoid arthritis (moderate to severe)
• Psoriatic arthritis
• Ankylosing spondylitis
• Ulcerative colitis (moderate to severe)
• Other autoimmune inflammatory conditions as prescribed by a physician

Dosage and Administration

• Administered orally as directed by a physician
• Commonly taken twice daily or once daily depending on condition and regimen
• Can be taken with or without food
• Regular monitoring is required during treatment

Possible Side Effects

Common side effects may include:

• Headache
• Upper respiratory tract infections
• Diarrhea
• Nausea
• Increased cholesterol levels

Serious side effects:

• Serious infections (bacterial, viral, or fungal)
• Tuberculosis reactivation
• Blood clots (deep vein thrombosis, pulmonary embolism)
• Liver enzyme abnormalities
• Reduced blood cell counts

Precautions

• Screen for tuberculosis before starting therapy
• Use with caution in patients with a history of infections
• Regular blood tests (CBC, liver function, lipid profile) are required
• Avoid live vaccines during treatment
• Not recommended during pregnancy unless clearly necessary

Contraindications

• Known hypersensitivity to Tofacitinib or any component
• Active serious infections
• Severe liver impairment

Drug Interactions

• Strong CYP3A4 inhibitors (may increase drug levels)
• Strong CYP3A4 inducers (may reduce effectiveness)
• Immunosuppressants may increase infection risk
• Live vaccines should be avoided

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Storage Instructions

• Store below 30°C
• Protect from moisture and direct sunlight
• Keep out of reach of children

Important Notes

Jakloc Tablet 5 mg is a potent immunomodulatory medicine that must be used under strict medical supervision. Regular monitoring is essential to ensure safety and effectiveness during long-term therapy.