Informet XR Tablet 500 mg contains Metformin Hydrochloride in an extended-release (XR) formulation. It is an oral antidiabetic medicine used for the management of type 2 diabetes mellitus. The extended-release technology allows gradual release of the active ingredient over a prolonged period, helping to maintain steady blood glucose levels while reducing gastrointestinal side effects commonly associated with immediate-release metformin. This formulation also supports convenient once-daily dosing, improving patient adherence to long-term therapy.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Therapeutic Class

Biguanides
Oral Antidiabetic Agent

Composition

Each extended-release tablet contains Metformin Hydrochloride 500 mg.

Indications

Informet XR Tablet 500 mg is indicated for:

• Treatment of type 2 diabetes mellitus in adults

• Glycemic control in patients not adequately managed by diet and exercise alone

• Use as monotherapy or in combination with other oral antidiabetic agents or insulin

It is particularly suitable for newly diagnosed patients or those requiring a lower starting dose with improved tolerability.

Pharmacology

Metformin belongs to the biguanide class of antidiabetic agents and lowers blood glucose without stimulating insulin secretion. Its primary actions include:

• Decreasing hepatic glucose production

• Reducing intestinal absorption of glucose

• Enhancing insulin sensitivity by increasing peripheral glucose uptake and utilization

The extended-release formulation of Informet XR ensures slow absorption of metformin, resulting in more stable plasma concentrations and minimizing peak-related gastrointestinal adverse effects. This leads to effective and sustained glycemic control throughout the day with a low risk of hypoglycemia when used alone.

Dosage and Administration

The dosage of Informet XR Tablet 500 mg should be individualized based on blood glucose levels and patient response.

• Typically administered once daily with the evening meal

• Tablets should be swallowed whole and must not be crushed, split, or chewed

Dose titration should be done gradually to enhance tolerability. Treatment decisions should always be made under the supervision of a qualified healthcare professional.

Contraindications

Informet XR Tablet 500 mg is contraindicated in patients with:

• Severe renal impairment

• Acute or chronic metabolic acidosis, including diabetic ketoacidosis

• Known hypersensitivity to metformin hydrochloride

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Precautions and Warnings

• Renal function should be assessed before initiation and monitored regularly

• Use with caution in elderly patients and those with conditions predisposing to hypoxia

• Temporary discontinuation may be required before major surgery or procedures involving iodinated contrast agents

• Although rare, lactic acidosis is a serious potential adverse effect and requires careful patient selection

Adverse Effects

Common adverse effects may include:

• Nausea

• Diarrhea

• Abdominal discomfort

• Reduced appetite

These effects are generally mild and transient and occur less frequently with extended-release formulations. Long-term use may be associated with reduced vitamin B12 levels.

Drug Interactions

Caution is advised when Informet XR is used with:

• Alcohol

• Iodinated contrast media

• Diuretics and certain antihypertensive medicines

Close monitoring is recommended when combined with other antidiabetic agents to avoid hypoglycemia.

Storage

Store in a cool and dry place, protected from light and moisture. Keep out of reach of children.

Conclusion

Informet XR Tablet 500 mg is a well-tolerated extended-release formulation of metformin designed to provide sustained blood glucose control with simplified once-daily dosing. It is an effective and reliable option for the long-term management of type 2 diabetes mellitus, supporting improved tolerability and patient compliance.