Perinase 50 mcg/spray contains Fluticasone Propionate, a potent topical corticosteroid with strong anti-inflammatory activity and minimal systemic absorption when used as directed. It is specially formulated for the management of corticosteroid-responsive inflammatory and pruritic skin conditions. Perinase is designed to provide effective symptom relief while maintaining a favorable safety profile compared to many conventional topical steroids.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Indications

Perinase 50 mcg/spray is indicated for the relief of inflammatory and pruritic manifestations associated with corticosteroid-responsive dermatoses, including:

• Eczema

• Dermatitis and other inflammatory skin conditions responsive to corticosteroid therapy

Therapeutic Class

Fluticasone & Combined Preparations (Topical Corticosteroid)

Pharmacology

Fluticasone propionate is a synthetic glucocorticoid with high topical anti-inflammatory potency and a low risk of hypothalamic-pituitary-adrenal (HPA) axis suppression following dermal application. This favorable therapeutic index makes it safer for topical use compared to many other potent corticosteroids.

Fluticasone propionate exhibits a high degree of selectivity and strong agonist activity at human glucocorticoid receptors, which are primarily responsible for its anti-inflammatory, antipruritic, and vasoconstrictive effects. In vitro studies demonstrate its strong receptor affinity, while showing weak interaction with progesterone receptors and virtually no affinity for mineralocorticoid, estrogen, or androgen receptors.

The clinical potency of Fluticasone propionate is related to the prolonged half-life of the glucocorticoid-receptor complex, which is approximately 10 hours, allowing sustained anti-inflammatory activity with minimal systemic exposure.

Dosage and Administration

Dosage should be based on the severity of the condition and patient response.

• Cream: Apply a thin layer of Fluticasone propionate cream to the affected area once daily.

• Ointment: Apply a thin layer of Fluticasone propionate ointment to the affected area twice daily.

Use should be limited to the shortest duration necessary to control symptoms.

Contraindications

Perinase 50 mcg/spray is contraindicated in:

• Rosacea

• Acne vulgaris

• Perioral dermatitis

• Primary cutaneous viral infections (e.g., herpes simplex, chicken pox)

• Hypersensitivity to Fluticasone propionate or any component of the formulation

• Perianal and genital pruritus

It is not indicated for primarily infected skin lesions caused by fungi or bacteria, nor for dermatoses in children under one year of age, including napkin eruptions.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Side Effects

Perinase 50 mcg/spray is generally well tolerated. Reported side effects include:

• Local burning sensation

• Pruritus

• Skin irritation

Prolonged or intensive use of potent corticosteroids may cause local skin changes such as thinning of the skin, striae, dilated superficial blood vessels, hypertrichosis, and hypopigmentation. Secondary infections, allergic contact dermatitis, and worsening of existing dermatoses have also been reported. Extensive or prolonged use, especially under occlusive dressings or in children, may result in systemic absorption leading to features of hypercorticism.

Pregnancy and Lactation

Use during pregnancy should be considered only if the potential benefit to the mother outweighs the possible risk to the fetus. The excretion of Fluticasone propionate in human breast milk has not been established. When used in lactating mothers, the benefits should be weighed carefully against potential risks to the infant.

Precautions and Warnings

Caution is advised when applying to large body surface areas or using for prolonged periods, particularly in infants and children, due to the risk of adrenal suppression. Facial skin is more susceptible to atrophic changes with long-term use. In infected inflammatory lesions, appropriate antimicrobial therapy should be initiated, and corticosteroid treatment discontinued if infection spreads.

Overdose

Acute overdose is unlikely. Chronic overuse or misuse may result in signs of hypercorticism, in which case treatment should be gradually discontinued. Accidental oral ingestion is unlikely to cause toxicity due to very low oral bioavailability.

Storage Conditions

Store below 30°C. Do not freeze. Keep out of reach of children.