Florium Tablet 10 mg contains Flunarizine, a selective calcium channel blocker with antihistaminic properties. It is widely used for the prevention of migraine and the management of vestibular disorders. Florium Tablet 10 mg helps reduce the frequency and severity of migraine attacks and alleviates symptoms associated with balance and inner ear disturbances, thereby improving overall quality of life.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Indications

Florium Tablet 10 mg is indicated for the following conditions:

• Prophylaxis of migraine (reduces frequency, duration, and intensity of attacks)

• Treatment of vestibular disorders such as vertigo

• Management of symptoms including dizziness, nausea, vomiting, and balance disturbances associated with vestibular dysfunction

Therapeutic Class

Calcium Channel Blocker / Antimigraine Agent

Pharmacology

Flunarizine acts primarily by blocking calcium influx through voltage-dependent calcium channels in neurons. By limiting excessive calcium entry into cells, it stabilizes neuronal excitability and improves cerebral blood flow. This mechanism plays a significant role in preventing migraine attacks. Additionally, its antihistaminic action contributes to its effectiveness in controlling vestibular symptoms such as vertigo and motion-related nausea. Flunarizine also exhibits mild sedative properties, which may be beneficial in patients experiencing associated sleep disturbances.

Dosage and Administration

• Adults: Typically 5–10 mg once daily, preferably in the evening

• Migraine Prophylaxis: Initial dose is often 10 mg daily, which may be reduced to 5 mg based on response and tolerability

• Elderly: Recommended starting dose is 5 mg daily

• Duration of Treatment: Long-term use should be periodically evaluated by a physician to minimize the risk of adverse effects

Dosage adjustments should always be made under medical supervision.

Drug Interactions

Florium Tablet 10 mg may enhance the sedative effects of alcohol, hypnotics, tranquilizers, and other central nervous system depressants. Concomitant use with antiepileptic drugs may require careful monitoring. Patients should inform their healthcare provider of all medications they are taking before starting Flunarizine.

Contraindications

Florium Tablet 10 mg is contraindicated in patients with:

• Known hypersensitivity to flunarizine or any component of the formulation

• History of depressive illness or current depression

• Parkinson’s disease or other extrapyramidal disorders

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Side Effects

Commonly reported side effects include:

• Drowsiness or fatigue

• Increased appetite and weight gain

• Dry mouth

• Constipation

Long-term use may be associated with mood changes, including depressive symptoms, and extrapyramidal effects, especially in elderly patients.

Pregnancy and Lactation

The safety of flunarizine during pregnancy has not been fully established. Florium Tablet 10 mg should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Caution is advised when administered to breastfeeding mothers, as it may be excreted in breast milk.

Precautions and Warnings

Florium Tablet 10 mg should be used with caution in patients with a history of depression, Parkinsonism, or other movement disorders. Regular monitoring is recommended during prolonged therapy to detect early signs of depression or motor impairment.

Use in Special Populations

• Elderly: Increased susceptibility to extrapyramidal symptoms; lower doses are recommended

• Hepatic Impairment: Use with caution; dose adjustment may be necessary.