Omastin 50 mg is a broad-spectrum triazole antifungal agent containing fluconazole, widely used for the treatment and prevention of various fungal infections. It works by inhibiting essential fungal enzymes required for cell membrane formation, making it highly effective against both superficial and systemic mycotic infections. Omastin 50 mg is suitable for use in normal individuals as well as in immunocompromised patients, including those with cancer, AIDS, or undergoing cytotoxic therapy.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Indications

Omastin 50 mg is indicated for the treatment and prevention of a wide range of fungal infections, including:

• Vaginal candidiasis (acute or recurrent)

• Candidal balanitis

• Mucosal candidiasis such as oropharyngeal, oesophageal, non-invasive bronchopulmonary infections, candiduria, mucocutaneous candidiasis, and chronic oral atrophic candidiasis

• Dermatophytic infections including tinea pedis, tinea cruris, tinea versicolor, and dermal candidial infections

• Nail fungal infections

• Systemic candidiasis including candidaemia and disseminated candidiasis

• Cryptococcosis including cryptococcal meningitis and pulmonary or cutaneous infections

• Prevention of fungal infections in immunocompromised patients, particularly those with neutropenia following chemotherapy or radiotherapy

• Maintenance therapy to prevent relapse of cryptococcal disease in AIDS patients

• Other systemic fungal infections such as histoplasmosis and coccidioidomycosis

Therapeutic Class

• Drugs for Subcutaneous and Mycoses

Pharmacology

Omastin 50 mg contains fluconazole, a triazole antifungal that selectively inhibits fungal cytochrome P-450 dependent enzymes. These enzymes are essential for the synthesis of ergosterol, a key component of the fungal cell membrane. Inhibition of ergosterol synthesis leads to increased membrane permeability and fungal cell death, resulting in effective eradication of infection.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Dosage and Administration

Dosage varies depending on the type and severity of infection and should be guided by a physician.

• Vaginal candidiasis: 150 mg as a single oral dose

• Oropharyngeal candidiasis: 50 mg once daily for 7–14 days

• Systemic candidiasis: 200–400 mg daily depending on clinical response

• Cryptococcal meningitis: 400 mg on the first day, followed by 200 mg once daily for at least 6–8 weeks

• Dermatophytic infections: 50 mg once daily for 2–6 weeks

Pediatric dosing is weight-based and adjusted according to age and renal function.

Drug Interactions

Omastin 50 mg may interact with several medications including warfarin, sulphonylureas, phenytoin, rifampicin, cyclosporin, theophylline, and oral contraceptives. Careful monitoring and dose adjustment may be required when used concurrently.

Contraindications

• Known hypersensitivity to fluconazole or other triazole antifungal agents

Side Effects

Omastin 50 mg is generally well tolerated. Common side effects include:

• Nausea

• Abdominal discomfort

• Diarrhoea

• Flatulence

Rarely, rash or severe hypersensitivity reactions such as anaphylaxis may occur.

Pregnancy and Lactation

Omastin 50 mg is classified as US FDA Pregnancy Category C. It should be avoided during pregnancy and lactation unless the potential benefit outweighs the possible risk to the fetus or infant.

Precautions and Warnings

Caution is advised in patients with liver or renal impairment. Rare cases of serious hepatic toxicity and severe cutaneous reactions such as Stevens-Johnson syndrome have been reported. Liver function should be monitored during prolonged therapy.

Storage Conditions

Store in a dry place away from heat and light. Keep out of reach of children.