Imanix Tablet 400 mg contains Imatinib Mesylate, a targeted anticancer medication used in the treatment of various types of cancers, particularly blood cancers and certain solid tumors. It belongs to a class of drugs known as tyrosine kinase inhibitors (TKIs), which specifically block abnormal proteins responsible for cancer cell growth.

Imatinib has revolutionized the treatment of chronic myeloid leukemia (CML) and gastrointestinal stromal tumors (GIST), offering effective long-term disease control with targeted therapy.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

Each film-coated tablet contains:

• Imatinib Mesylate equivalent to Imatinib 400 mg

Mechanism of Action

Imatinib works by selectively inhibiting specific tyrosine kinases such as BCR-ABL, c-KIT, and platelet-derived growth factor receptor (PDGFR). These abnormal enzymes drive uncontrolled cell growth in certain cancers. By blocking these pathways, Imatinib prevents cancer cell proliferation and promotes apoptosis (cell death).

Indications

Imanix Tablet 400 mg is indicated for:

• Chronic myeloid leukemia (CML)
• Acute lymphoblastic leukemia (Philadelphia chromosome-positive)
• Gastrointestinal stromal tumors (GIST)
• Myelodysplastic/myeloproliferative disorders
• Hypereosinophilic syndrome
• Dermatofibrosarcoma protuberans

Dosage and Administration

• To be taken orally as prescribed by an oncologist
• Usually taken once daily with food and a full glass of water
• Tablets should be swallowed whole; do not crush or chew
• Dose depends on the condition and patient response
• Long-term treatment may be required

Contraindications

Imanix Tablet should not be used in:

• Known hypersensitivity to Imatinib or any component
• Severe liver impairment without medical supervision
• Pregnancy and breastfeeding unless clearly advised by a specialist

Side Effects

Common side effects include:

• Nausea and vomiting
• Edema (fluid retention)
• Muscle cramps
• Diarrhea
• Fatigue
• Skin rash

Serious side effects may include:

• Severe fluid retention (pleural effusion, edema)
• Liver toxicity
• Bone marrow suppression
• Cardiac complications (rare)

Precautions

• Regular monitoring of blood counts and liver function is required
• Use cautiously in patients with cardiac, liver, or kidney disorders
• Monitor for signs of fluid retention
• Avoid pregnancy during treatment
• Maintain adequate hydration

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Drug Interactions

Imanix Tablet may interact with:

• CYP3A4 inhibitors or inducers (affect drug levels)
• Anticoagulants (require monitoring)
• Other anticancer drugs
• Grapefruit products (may increase drug concentration)

Storage Conditions

• Store below 30°C in a dry place
• Protect from light and moisture
• Keep out of reach of children.