Glipita M XR Tablet 50 mg+500 mg is a fixed-dose combination of Sitagliptin and Metformin Hydrochloride (Extended Release), designed for the effective management of type 2 diabetes mellitus in adults. This combination therapy targets multiple pathophysiological defects of diabetes, helping achieve better and sustained glycemic control when lifestyle modification alone or monotherapy is inadequate.

The extended-release formulation of metformin ensures gradual drug release, improving gastrointestinal tolerability and allowing convenient once-daily dosing.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Therapeutic Class

DPP-4 Inhibitor + Biguanide (Antidiabetic Combination)

Pharmacology

Sitagliptin is a selective dipeptidyl peptidase-4 (DPP-4) inhibitor. It increases endogenous incretin hormone levels (GLP-1 and GIP), which enhance glucose-dependent insulin secretion and suppress glucagon release from the pancreas. This leads to reduced hepatic glucose production and improved postprandial and fasting blood glucose control.

Metformin Hydrochloride primarily reduces hepatic glucose output and improves peripheral insulin sensitivity by increasing glucose uptake and utilization in muscle tissues. It also decreases intestinal glucose absorption. The extended-release formulation provides sustained plasma levels and reduces common gastrointestinal side effects associated with immediate-release metformin.

The complementary mechanisms of action of Sitagliptin and Metformin result in effective glucose control with a low risk of hypoglycemia.

Indications

Glipita M XR Tablet is indicated for:

• Treatment of type 2 diabetes mellitus in adults

• Patients inadequately controlled on metformin or sitagliptin alone

• Use as add-on therapy along with diet and exercise

Dosage and Administration

The usual recommended dose is one tablet once daily, preferably taken with the evening meal. Tablets should be swallowed whole and not crushed, chewed, or split. Dose adjustments should be individualized based on glycemic response, tolerability, and renal function. Treatment should be initiated and supervised by a registered physician.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Benefits and Features

• Dual action for superior glycemic control

• Extended-release metformin for better gastrointestinal tolerance

• Low risk of hypoglycemia when used appropriately

• Weight-neutral or modest weight benefit

• Convenient once-daily dosing

Use in Special Populations

• Renal impairment: Contraindicated in severe renal dysfunction; dose adjustment required in moderate impairment

• Elderly patients: Renal function should be assessed regularly

• Pregnancy and lactation: Use only if clearly indicated and prescribed by a physician

Side Effects

Commonly reported side effects may include:

• Nausea or mild gastrointestinal discomfort

• Diarrhea or abdominal pain

• Headache

• Upper respiratory tract infections

Rare but serious adverse effects such as lactic acidosis or pancreatitis require immediate medical attention.

Precautions and Warnings

• Not indicated for type 1 diabetes or diabetic ketoacidosis

• Periodic monitoring of renal function is essential

• Temporary discontinuation may be required before radiologic procedures using iodinated contrast

Storage

Store below 30°C in a dry place. Protect from light and moisture. Keep out of reach of children.